Evidence map›Paper›PMID 38389847›Full record

ArticleTheranostics2024

High-content stimulated Raman histology of human breast cancer.

Hongli Ni, Chinmayee Prabhu Dessai, Haonan Lin, Wei Wang, Shaoxiong Chen, Yuhao Yuan, Xiaowei Ge, Jianpeng Ao, Nolan Vild, Ji-Xin Cheng

Abstract read
In one paragraph

Article in Theranostics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongli NiDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02215, USA.
Chinmayee Prabhu DessaiDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, MA 02215, USA.
Haonan LinDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02215, USA.
Wei WangHologic Inc., 250 campus drive, Marlborough, MA 01752, USA.
Shaoxiong ChenIndiana University School of Medicine 340 West 10th Street, Fairbanks Hall, Suite 6200, IN 46202, USA.
Yuhao YuanDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02215, USA.
Xiaowei GeDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02215, USA.
Jianpeng AoDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02215, USA.
Nolan VildDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02215, USA.
Ji-Xin ChengDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St., Boston, MA, 02215, USA.

Funding

Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7M
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data ScienceR01EB032391 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2022 to 2025
$2.0M
NIBIB NIH HHS R01 EB032391NIGMS NIH HHS R35 GM136223
6 · The paper itself

Abstract

Histological examination is crucial for cancer diagnosis, however, the labor-intensive sample preparation involved in the histology impedes the speed of diagnosis. Recently developed two-color stimulated Raman histology could bypass the complex tissue processing to generates result close to hematoxylin and eosin staining, which is one of the golden standards in cancer histology. Yet, the underlying chemical features are not revealed in two-color stimulated Raman histology, compromising the effectiveness of prognostic stratification. Here, we present a high-content stimulated Raman histology (HC-SRH) platform that provides both morphological and chemical information for cancer diagnosis based on un-stained breast tissues.

Indexed as

Breast NeoplasmsEosine Yellowish-(YS)Extracellular Matrix ProteinsFemaleHematoxylinHumansLipidsWaterEosine Yellowish-(YS)Extracellular Matrix ProteinsHematoxylinLipidsWaterbreast cancerfiber laserhigh-content chemical imaginglabel-free histologystimulated Raman histology

Identifiers

PMID38389847
PMCPMC10879861

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.