Evidence map›Paper›PMID 38389717›Full record

ArticleProceedings. IEEE International Conference on Bioinformatics and Biomedicine2023

A generalizable physiological model for detection of Delayed Cerebral Ischemia using Federated Learning.

Ahmed Elhussein, Murad Megjhani, Daniel Nametz, Miriam Weiss, Jude Savarraj, Soon Bin Kwon, David J Roh, Sachin Agarwal, E Sander Connolly, Angela Velazquez and 5 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings. IEEE International Conference on Bioinformatics and Biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Ahmed ElhusseinDepartment of Biomedical Informatics, Columbia University, New York Genome Center, New York, NY, USA.
Murad MegjhaniDepartment of Neurology, Columbia University, New York, NY, USA.
Daniel NametzDepartment of Neurology, Columbia University, New York, NY, USA.
Miriam WeissDepartment of Neurosurgery, RWTH Aachen University, Aachen, Germany.
Jude SavarrajDepartment of Neurology, UT Health, Houston, TX, USA.
Soon Bin KwonDepartment of Neurology, Columbia University, New York, NY, USA.
David J RohDepartment of Neurology, Columbia University, New York, NY, USA.
Sachin AgarwalDepartment of Neurology, Columbia University, New York, NY, USA.
E Sander ConnollyDepartment of Neurology, Columbia University, New York, NY, USA.
Angela VelazquezDepartment of Neurology, Columbia University, New York, NY, USA.
Jan ClaassenDepartment of Neurology, Columbia University, New York, NY, USA.
Huimahn A ChoiDepartment of Neurosurgery, RWTH Aachen University, Aachen, Germany.
Gerrit A SchubertDepartment of Neurosurgery, Kantonsspital, Aarau, Switzerland.
Soojin ParkDepartment of Neurology, Department of Biomedical Informatics, Columbia University, New York, NY, USA.
Gamze GürsoyDepartment of Biomedical Informatics, Department of Computer Science, Columbia University, New York Genome Center, New York, NY, USA.
Columbia University · USRWTH Aachen University · DEKantonsspital Baden · CHNew York Genome Center · USThe University of Texas Health Science Center at Houston · US

Funding

Machine Learning to Optimize Management of Acute HydrocephalusR01NS131606 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Soojin Park · 2023 to 2026
$2.6M
ContinuOuS Monitoring Tool for Delayed Cerebral IsChemia (COSMIC)R01NS129760 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Soojin Park · 2023 to 2026
$2.5M
Tools to Address the Challenges of Preserving Privacy in Sharing and Analysis of Biomedical DataR35GM147004 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GURSOY, GAMZE · 2022 to 2025
$1.8M
Realistic quantification of potential privacy loss from genomic summary resultsR00HG010909 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GURSOY, GAMZE · 2022 to 2024
$727k
NHGRI NIH HHS R00 HG010909NIGMS NIH HHS R35 GM147004NINDS NIH HHS R01 NS129760NINDS NIH HHS R01 NS131606
6 · The paper itself

Abstract

Delayed cerebral ischemia (DCI) is a complication seen in patients with subarachnoid hemorrhage stroke. It is a major predictor of poor outcomes and is detected late. Machine learning models are shown to be useful for early detection, however training such models suffers from small sample sizes due to rarity of the condition. Here we propose a Federated Learning approach to train a DCI classifier across three institutions to overcome challenges of sharing data across hospitals. We developed a framework for federated feature selection and built a federated ensemble classifier. We compared the performance of FL model to that obtained by training separate models at each site. FL significantly improved performance at only two sites. We found that this was due to feature distribution differences across sites. FL improves performance in sites with similar feature distributions, however, FL can worsen performance in sites with heterogeneous distributions. The results highlight both the benefit of FL and the need to assess dataset distribution similarity before conducting FL.

Indexed as

Federated LearningStroke

Identifiers

PMID38389717
PMCPMC10883332
OpenAlexW4390992113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.