ArticleEClinicalMedicine2024
Ultra-processed food consumption and risk of cardiovascular events: a systematic review and dose-response meta-analysis.
Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Ultra-processed food consumption and risk of multiple chronic diseases among 8,819,894 adults from 51 prospective cohorts: a dose-response meta-analysis.Family medicine and community health · 2026Pooled it
- Ultra-processed foods consumption and health-related outcomes: a systematic review of randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Associations Between Ultra-Processed Food (UPF) Consumption and Weight Change and Obesity Risk Among Consumers of Plant-Based Diets: A Systematic Review.Journal of the American Nutrition AssociationPooled it
- Health and environmental co-benefits of reducing ultra-processed food consumption in Argentina: a modelling study.Environmental research letters : ERL [Web site] · 2026Article
- Metabolomic profiling of ultra-processed food consumption and cardiovascular risk in Spanish preschool children: a cross-sectional study.EBioMedicine · 2026Article
- Association Between Hypertensive Disorders of Pregnancy, Lifestyle Factors, and Premature Cardiovascular Events.JACC. Advances · 2026Article
- Ultra-processed food consumption in Scotland: a nationally representative analysis of sociodemographic patterns and dietary contributions.Public health nutrition · 2026Article
- Development and application of a healthy plant content estimation algorithm for Australian packaged foods.Nutrition journal · 2026Article
- Review
- Gene-diet interactions in cardiovascular disease: insights from nutrigenetics, nutrigenomics, and precision nutrition.Frontiers in nutrition · 2026Review
- Ultra-processed food exposure and health outcomes: Current evidence, controversies, and future perspectives.EXCLI journal · 2026Review
- Nutrition Patterns, Metabolic and Psychological State Among High-Weight Young Adults: A Network Approach.Nutrients · 2026Article
- Impact of a novel ultra-processed foods and drinks diet on metabolism and behaviour in adolescent female and male rats.Scientific reports · 2025Article
- Ultra-Processed Food Consumption and Systemic Inflammatory Biomarkers: A Scoping Review.Nutrients · 2025Article
- Ten-year trajectories of ultra-processed food intake and prospective associations with cardiovascular diseases and all-cause mortality: findings from the Whitehall II cohort study.Nutrition journal · 2025Article
- Existing food processing classifications overlook the phytochemical composition of processed plant-based protein-rich foods.Nature food · 2025Article
- Advanced glycation end-product intake predicts insulin resistance in a sex-dependent fashion.European journal of nutrition · 2025Article
- Ultra-Processed Food and Its Impact on Bone Health and Joint Diseases: A Scoping Review.Nutrients · 2025Article
- Mediterranean Diet and Ultra-Processed Food Intake in Older Australian Adults-Associations with Frailty and Cardiometabolic Conditions.Nutrients · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ultra-processed food (UPF) consumption continues to increase worldwide. However, evidences from meta-analyses are limited regarding the effects on cardiovascular events (CVEs). Methods: A meta-analysis was performed to assess the dose-response relationship of UPF consumption and CVEs risk (including the morbidity and mortality of cardiovascular causes, and myocardial infarction, stroke, transient ischemic attack, coronary intervention). Databases (PubMed, EMBASE, Cochrane Library, and Web of Science) were searched for observational studies published in English language up to October 24, 2023. Generalized least squares regression and restricted cubic splines were used to estimate the linear/nonlinear relationship. PROSPERO CRD 42023391122. Findings: Twenty studies with 1,101,073 participants and 58,201 CVEs cases with a median follow-up of 12.2 years were included. A positive linear relationship between UPF intake and CVEs risk was identified. In addition, positive correlation between coronary heart disease and UPF consumption in terms of daily serving and daily energy proportion. No significant association of UPF consumption with the risk of cerebrovascular disease was observed. Briefly, 10% increase of UPF by daily weight proportion was associated with a 1.9% increase of CVEs risk (RR = 1.019; 95% CI, 1.007-1.031; Interpretation: UPF consumption were associated with a higher risk of CVEs in the positive linear relationship. Our findings highlight the importance of minimizing UPF consumption for cardiovascular health and might be help to pursue public health policies in control of UPF consumption. Funding: This work was supported by the Key Research and Development Program of Shaanxi Province (2023-ZDLSF-22), the Innovative Talent Support Program of Shaanxi Province (2022KJXX-106), and the Key Research and Development Program of Shaanxi Province (2023-YBSF-424).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.