Evidence map›Paper›PMID 38389471›Full record

ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2024

Outcomes of transcatheter edge-to-edge repair for atrial functional mitral regurgitation.

Tetsu Tanaka, Atsushi Sugiura, Johanna Vogelhuber, Can Öztürk, Lukas Böhm, Nihal Wilde, Sebastian Zimmer, Georg Nickenig, Marcel Weber

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. 2025 ESC/EACTS valvular heart disease guidelines: practical updates on mitral and tricuspid regurgitation.European heart journal supplements : journal of the European Society of Cardiology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Between Scylla and Charybdis in atrial functional mitral regurgitation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tetsu TanakaHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Atsushi SugiuraHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Johanna VogelhuberHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Can ÖztürkHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Lukas BöhmHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Nihal WildeHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Sebastian ZimmerHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Georg NickenigHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Marcel WeberHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
University Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic benefits of transcatheter edge-to-edge repair (TEER) remain unclear in patients with atrial functional mitral regurgitation (AFMR).

aimsWe aimed to investigate the clinical outcomes of TEER for patients with AFMR.

methodsWe retrospectively classified functional mitral regurgitation (FMR) patients undergoing TEER into those with AFMR or ventricular FMR (VFMR). A residual MR ≤1+ at discharge was considered optimal mitral regurgitation (MR) reduction, and an elevated mean mitral valve pressure gradient (MPG) was defined as an MPG ≥5 mmHg at discharge. The primary outcome was a composite of all-cause mortality and hospitalisation due to heart failure within one year.

resultsOf 441 FMR patients, 125 patients were considered as having AFMR. Residual MR ≤1+ was associated with a lower risk of the composite outcome in both AFMR and VFMR patients, while an MPG ≥5 mmHg was associated with a higher risk of the composite outcome in patients with AFMR but not with VFMR. AFMR patients with residual MR ≤1+ and an MPG ≥5 mmHg, as well as those with residual MR >1+, had a higher incidence of the composite outcome than those with residual MR ≤1+ and an MPG <5 mmHg (50.7%, 41.8%, and 14.3%, respectively; p<0.001). This association was consistent after adjustment for clinical and echocardiographic characteristics.

conclusionsAn MR reduction to ≤1+ following TEER was associated with a lower risk of clinical outcomes in patients with AFMR, while an MPG ≥5 mmHg was related to a higher risk of clinical outcomes. Optimal MR reduction by TEER may have potential benefits on the prognosis of patients with AFMR, although the prognostic benefit may be attenuated by an elevated MPG.

Indexed as

Mitral Valve InsufficiencyHeart AtriaHeart VentriclesHumansMitral ValveRetrospective Studies

Identifiers

PMID38389471
PMCPMC10870009
OpenAlexW4391886783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.