Evidence map›Paper›PMID 38389258›Full record

ArticleThe veterinary quarterly2024

Serum protein electrophoresis in European mink (

Sergio Villanueva-Saz, María Del Carmen Aranda, María de Los Ángeles Jiménez, Paloma Jimena de Andrés, Maite Verde, María Climent, María Eugenia Lebrero Berna, Diana Marteles Aragüés, Antonio Fernández

Open access · goldAbstract read
In one paragraph

Article in The veterinary quarterly, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sergio Villanueva-SazAnimal Pathology Department, Veterinary Faculty, Zaragoza University, Zaragoza, Spain.
María Del Carmen ArandaFIEB Foundation (Fundación para la Investigación en etología y biodiversidad), Toledo, Spain.
María de Los Ángeles JiménezDepartment of Animal Medicine and Surgery, Veterinary Faculty, Complutense University of Madrid, Madrid, Spain.
Paloma Jimena de AndrésDepartment of Animal Medicine and Surgery, Veterinary Faculty, Complutense University of Madrid, Madrid, Spain.
Maite VerdeAnimal Pathology Department, Veterinary Faculty, Zaragoza University, Zaragoza, Spain.
María ClimentDepartment of Anatomy, Embryology and Animal Genetic, Veterinary Faculty, Zaragoza University, Zaragoza, Spain.
María Eugenia Lebrero BernaAnimal Pathology Department, Veterinary Faculty, Zaragoza University, Zaragoza, Spain.
Diana Marteles AragüésAnimal Pathology Department, Veterinary Faculty, Zaragoza University, Zaragoza, Spain.
Antonio FernándezAnimal Pathology Department, Veterinary Faculty, Zaragoza University, Zaragoza, Spain.
Universidad de Zaragoza · ESUniversidad Complutense de Madrid · ESCentro de Investigación y Tecnología Agroalimentaria de Aragón · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKnowledge of reference intervals for blood analytes, including serum protein fractions, is of great importance for the identification of infectious and inflammatory diseases and is often lacking in wild animal species. MATERIAL AND

methodsSerum samples were obtained from European minks enrolled in the breeding program (n = 55). Agarose gel electrophoresis (AGE) and capillary zone electrophoresis (CZE) were used to separate and identify protein fractions. Albumin, α1, α2, β, and γ-globulins fractions were identified in all mink sera by both electrophoresis methods. Reference intervals (90% CI) were determined following the 2008 guidelines of the Clinical Laboratory Standard Institute. The methods were compared using Passing-Bablok regression, Bland-Altman analysis, and Lin's concordance correlation.

resultsA significant bias was found between methods for α1, α2, and γ-globulin. Lin's concordance correlation was considered unacceptable for α1, α2, and β-globulins. Differences for gender between methods were found for albumin and α2-globuins, which were higher for males than females. γ-globulins were higher for adults than young minks using both methods; however, α1 and α2-globulins were lower.

conclusionBoth methods are adequate for identifying serum protein disorders, but the AGE and CZE methods are not equivalent. Therefore, reference intervals for each technique are required.

Indexed as

Blood ProteinsMinkAlbuminsAnimalsElectrophoresis, Agar GelElectrophoresis, CapillaryFemalegamma-GlobulinsMaleReference ValuesAlbuminsBlood Proteinsgamma-GlobulinsageAGEconcordance analysisCZEelectrophoresisEuropean minkreference intervalsserum protein gender

Identifiers

PMID38389258
PMCPMC10896155
OpenAlexW4392109372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.