ArticleBMC public health2024
Trajectories network analysis of chronic diseases among middle-aged and older adults: evidence from the China Health and Retirement Longitudinal Study (CHARLS).
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 20 citations in OpenAlex.
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- Associations between continuous health examinations and trajectories of comorbidity of chronic disease: Evidence from a nationwide longitudinal study of middle-aged and older adults in China.Global health research and policy · 2026Article
- Longitudinal dynamic relationships among social frailty, depression, cognitive function, and physical frailty in community-dwelling older adults: A random intercept cross-lagged panel model study.International journal of nursing studies advances · 2026Article
- Cross-cultural Adaptation and Psychometric Properties of the Chinese Version of the Spiritual Needs Questionnaire (SpNQ-20) Among Older Adults with Chronic Diseases in China.Journal of religion and health · 2026Article
- Chronic disease comorbidity and its impact on healthcare utilization among older adults in China: a cross-sectional and longitudinal analysis.BMC geriatrics · 2026Article
- Ten-year population-based assessment of multimorbidity burden progression in a regional cohort of 5.5 million adults.NPJ digital medicine · 2026Article
- Depressive symptom trajectories and the association with diabetes and cardiovascular diseases in middle-aged and older Chinese adults: a cohort study.BMC public health · 2026Article
- The role of diet and periodontitis in preserved ratio impaired spirometry: a mediation analysis.Frontiers in nutrition · 2026Article
- Gender Difference in Satisfaction with Nursing Home Services Among Disabled Elderly Inpatients Across Disease Categories: A Multi-Center Study.Patient preference and adherence · 2026Article
- A Network Analysis of Medication Literacy and Associated Psychological Factors in Patients with Coronary Heart Disease and Diabetes.Patient preference and adherence · 2026Article
- Hypertriglyceridemic waist-to-height ratio and the triple burden of hypertension, diabetes, and dyslipidemia in adults: association and network analysis.Frontiers in endocrinology · 2026Article
- Body Shape Indices and Chronic Knee Pain in Chinese Aging Population: A Longitudinal Analysis of Abdominal Obesity, BMI, and Waist Circumference.Journal of obesity · 2026Observational
- Association between extreme temperature events and multimorbidity among older adults: evidence from the CHARLS.BMC medicine · 2025Article
- Multimorbidity patterns of mental disorders and physical diseases of adults in northeast China: a cross-sectional network analysis.Epidemiology and psychiatric sciences · 2025Article
- Development of a Longitudinal Model for Disability Prediction in Older Adults in China: Analysis of CHARLS Data (2015-2020).JMIR aging · 2025Article
- Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study.Investigative ophthalmology & visual science · 2025Article
- Network analysis of chronic disease among middle-aged and older adults in China: a nationwide survey.Frontiers in public health · 2025Article
- Article
- Pain Status and Disability in Activities of Daily Living Among Older Adults in China: Evidence From CHARLS 2020.Pain research & management · 2025Article
- Activities of Daily Living Disability Transition Patterns in Older Adults with Chronic Diseases: A Four-Year Cohort Study in China.Healthcare (Basel, Switzerland) · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
backgroundGiven the increased risk of chronic diseases and comorbidity among middle-aged and older adults in China, it is pivotal to identify the disease trajectory of developing chronic multimorbidity and address the temporal correlation among chronic diseases.
methodThe data of 15895 participants from the China Health and Retirement Longitudinal Study (CHARLS 2011 - 2018) were analyzed in the current study. Binomial tests and the conditional logistic regression model were conducted to estimate the associations among 14 chronic diseases, and the disease trajectory network analysis was adopted to visualize the relationships.
resultsThe analysis showed that hypertension is the most prevalent disease among the 14 chronic conditions, with the highest cumulative incidence among all chronic diseases. In the disease trajectory network, arthritis was found to be the starting point, and digestive diseases, hypertension, heart diseases, and dyslipidemia were at the center, while memory-related disease (MRD), stroke, and diabetes were at the periphery of the network.
conclusionsWith the chronic disease trajectory network analysis, we found that arthritis was prone to the occurrence and development of various other diseases. In addition, patients of heart diseases/hypertension/digestive disease/dyslipidemia were under higher risk of developing other chronic conditions. For patients with multimorbidity, early prevention can preclude them from developing into poorer conditions, such as stroke, MRD, and diabetes. By identifying the trajectory network of chronic disease, the results provided critical insights for developing early prevention and individualized support services to reduce disease burden and improve patients' quality of life.
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