ArticleBMC public health2024
Associations between patterns of blood heavy metal exposure and health outcomes: insights from NHANES 2011-2016.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Recent Advances in Paper-Based Microfluidic Devices for Heavy Metal Ion Detection: A Review.Micromachines · 2026Review
- Association between the ratio of uric acid to high-density lipoprotein cholesterol (UHR) and the abnormal risk of sarcopenia: Evidence from two large population-based surveys and interpretable machine learning-driven sarcopenia screening.Therapeutic advances in endocrinology and metabolism · 2026Article
- Essential and Toxic Elements in Cardiovascular Disease: Pathophysiological Roles and the Emerging Contribution of Hair Mineral Analysis.International journal of molecular sciences · 2025Review
- Heavy Metals Like Aluminum, Arsenic, Cadmium, Chromium, Copper, Iron, Lead, Manganese, Mercury, Nickel, and Zinc Polluting the Drinking Water: Their Individual Health Hazards.International journal of molecular sciences · 2025Review
- Association Between Heavy Metals Exposure and Elevated High-Sensitivity C-Reactive Protein: Mediating Role of Body Mass Index.Biomolecules · 2025Article
- Association Between Multiple Plasma Toxic Metal and Metalloid Exposures and Hypertension in Elderly Chinese Adults.Biological trace element research · 2025Article
- Association of PFAS and Metals with Cardiovascular Disease Risk: Exploring the Mediating Effect of Diet.Environments (Basel, Switzerland) · 2025Article
- Associations between urinary and blood heavy metal exposure and heart failure in elderly adults: Insights from an interpretable machine learning model based on NHANES (2003-2020).International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Assessing Heavy Metal Contamination in Food: Implications for Human Health and Environmental Safety.Toxics · 2025Review
- Heavy metal contamination in tampons: A hidden public health concern.Environmental analysis, health and toxicology · 2025Article
- Selenium and Lead Exposure are Associated with Elevated Blood Pressure in Individuals with Undiagnosed Hypertension: Findings from NHANES 2013-2020.Vascular health and risk management · 2025Article
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- Association between blood heavy metals and fecal incontinence in American adults: A population-based study.BMC public health · 2024Article
- Single and joint exposure of Pb, Cd, Hg, Se, Cu, and Zn were associated with cognitive function of older adults.Scientific reports · 2024Article
- Association between exposure to urinary metal and all-cause and cardiovascular mortality in US adults.PloS one · 2024Article
- A multi-year heavy metal analysis of 72 dark chocolate and cocoa products in the USA.Frontiers in nutrition · 2024Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExtensive research has explored the association between heavy metal exposure and various health outcomes, including malignant neoplasms, hypertension, diabetes, and heart diseases. This study aimed to investigate the relationship between patterns of exposure to a mixture of seven heavy metals and these health outcomes.
methodsBlood samples from 7,236 adults in the NHANES 2011-2016 studies were analyzed for levels of cadmium, manganese, lead, mercury, selenium, copper, and zinc. Cluster analysis and logistic regression identified three distinct patterns of mixed heavy metal exposure, and their associations with health outcomes were evaluated.
resultsPattern 1 exhibited higher odds ratios (ORs) for malignancy during NHANES 2011-2012 (OR = 1.33) and 2015-2016 (OR = 1.29) compared to pattern 2. Pattern 3 showed a lower OR for malignancy during NHANES 2013-2014 (OR = 0.62). For hypertension, pattern 1 displayed higher ORs than pattern 2 for NHANES 2011-2012 (OR = 1.26), 2013-2014 (OR = 1.31), and 2015-2016 (OR = 1.41). Pattern 3 had lower ORs for hypertension during NHANES 2013-2014 (OR = 0.72) and 2015-2016 (OR = 0.67). In terms of heart diseases, pattern 1 exhibited higher ORs than pattern 2 for NHANES 2011-2012 (OR = 1.34), 2013-2014 (OR = 1.76), and 2015-2016 (OR = 1.68). Pattern 3 had lower ORs for heart diseases during NHANES 2013-2014 (OR = 0.59) and 2015-2016 (OR = 0.52). However, no significant trend was observed for diabetes. All three patterns showed the strongest association with hypertension among the health outcomes studied.
conclusionsThe identified patterns of seven-metal mixtures in NHANES 2011-2016 were robust. Pattern 1 exhibited higher correlations with hypertension, heart disease, and malignancy compared to pattern 2, suggesting an interaction between these metals. Particularly, the identified patterns could offer valuable insights into the management of hypertension in healthy populations.
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