Evidence map›Paper›PMID 38388906›Full record

ArticleSurgery today2024

Incidence of atrial fibrillation after esophageal cancer surgery with L-carnitine use: a preliminary single-group interventional study.

Yasushige Shingu, Isao Yokota, Toshiaki Shichinohe, Soichi Murakami, Yuma Ebihara, Yo Kurashima, Satoshi Hirano, Satoru Wakasa

Abstract read
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In one paragraph

Article in Surgery today, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yasushige ShinguDepartment of Cardiovascular Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan. shingu@huhp.hokudai.ac.jp.
Isao YokotaDepartment of Biostatistics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Toshiaki ShichinoheDepartment of Gastroenterology Surgery II, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Soichi MurakamiDepartment of Gastroenterology Surgery II, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yuma EbiharaDepartment of Gastroenterology Surgery II, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yo KurashimaDepartment of Gastroenterology Surgery II, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Satoshi HiranoDepartment of Gastroenterology Surgery II, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Satoru WakasaDepartment of Cardiovascular Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan.
Hokkaido University · JP

Funding

The Japanese Association for Thoracic Surgery (JATS) Transitional clinical research prize 2018
6 · The paper itself

Abstract

purposeWe aimed to investigate the POAF rate and blood FABP4 levels after perioperative L-carnitine administration in patients with esophageal cancer.

methodsL-carnitine (3 g in three divided doses) was administered to 15 patients 2 days before and 3 days after surgery. POAF during the study period and blood FABP4 levels (ELISA) before and after L-carnitine administration were evaluated. Accurate 95% confidence intervals (CI) for POAF incidence and changes in blood FABP4 levels were calculated. The preoperative predicted POAF rate was calculated using an application for esophageal cancer. The correlation between FABP4 levels and the predicted POAF rate was analyzed using Pearson's coefficient (r).

resultsThirteen patients completed this study. The predicted POAF rate was 24% (17%, 34%) (median; interquartile range). The actual incidence of POAF was 7.7% (95% CI: 0.2-36%). Blood FABP4 levels changed from 10.3 to 7.0 ng/mL; the average change was - 3.3 (95% CI: - 6.6 to - 0.1). A positive correlation was found between preoperative FABP4 levels and the predicted POAF rates (r = 0.564).

conclusionsThe POAF rate after esophageal surgery was 7.7% for L-carnitine. L-carnitine may reduce blood FABP4 levels. This preliminary study will contribute to the planning of sample sizes in future randomized trials.

Indexed as

Atrial FibrillationCarnitineEsophageal NeoplasmsFatty Acid-Binding ProteinsPostoperative ComplicationsAgedEsophagectomyFemaleHumansIncidenceMaleMiddle AgedPerioperative CareCarnitineFABP4 protein, humanFatty Acid-Binding ProteinsCardiovascularEsophagusPostoperative atrial fibrillation

Identifiers

PMID38388906
OpenAlexW4392121637

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.