Evidence map›Paper›PMID 38388763›Full record

ArticleArchives of sexual behavior2024

Gender Incongruence and Autistic Traits: Cerebral and Behavioral Underpinnings.

Behzad S Khorashad, Yanlu Wang, Mats Holmberg, Cecilia Dhejne, Ivanka Savic

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of sexual behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Behzad S KhorashadDepartment of Women's and Children's Health, Karolinska Institute and University Hospital, 171 77, Stockholm, Sweden.
Yanlu WangRadiology Unit, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
Mats HolmbergANOVA, Karolinska University Hospital, Stockholm, Sweden.
Cecilia DhejneANOVA, Karolinska University Hospital, Stockholm, Sweden.
Ivanka SavicDepartment of Women's and Children's Health, Karolinska Institute and University Hospital, 171 77, Stockholm, Sweden. Ivanka.savic-berglund@ki.se.
Karolinska Institutet · SEKarolinska University Hospital · SE

Funding

Gender identity and own body perception implications for the neurobiology of gender dysphoriaR01HD087712 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, SAVIC-BERGLUND, IVANKA · 2017 to 2020
$2.3M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R01HD087712NICHD NIH HHS R01 HD087712Svenska Forskningsrådet Formas Dnr 200 7-3107
6 · The paper itself

Abstract

Gender dysphoria and autism spectrum disorder (ASD) co-occur at high rates. Yet, it is unknown whether gender dysphoria and ASD are associated with common or distinct neurobiological correlates or how they relate to experiences of gender-related body incongruence. Using the Social Responsiveness Scale, we assessed autistic traits in 99 transgender and 99 cisgender individuals and investigated their associations with gender-related body incongruence, measured via a visually based "Body Morph" test, and with cortical thickness in the brain. Autistic traits were significantly higher among transgender individuals, and those with higher autistic traits had higher body incongruence scoring. Among transgender individuals, higher autistic traits were linked with a thinner cortex bilaterally in the temporal pole and the superior and inferior temporal gyri. Autistic traits were only partly associated with cortical morphology patterns previously reported in transgender individuals; instead, they were primarily linked to temporal lobe areas mediating social cognition. While replicating the previous literature on the increased prevalence of autistic traits among transgender individuals, this study reports specific regions in the brains of transgender individuals where cortical thickness is associated with autistic traits.

Indexed as

Autism Spectrum DisorderGender DysphoriaTransgender PersonsAdolescentAdultAutistic DisorderBody ImageBrainCerebral CortexFemaleHumansMagnetic Resonance ImagingMaleTemporal LobeTranssexualismYoung AdultAutismBody incongruenceCortical thicknessGender incongruenceSocial Responsiveness Scale

Identifiers

PMID38388763
PMCPMC11106115
OpenAlexW4392024324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.