ArticleNature neuroscience2024
Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation.
Open access · hybridAbstract read
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Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
49.5field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Circuit-based neuromodulation for obsessive-compulsive disorder: a systematic review, meta-analysis, and translational case study.Journal of psychiatry & neuroscience : JPN · 2026Pooled it
- Advances in gait research related to Alzheimer's disease.Frontiers in neurology · 2025Pooled it
- Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.Cell reports. Medicine · 2026Trial
- Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.Nature communications · 2025Trial
- Subthalamic nucleus deep brain stimulation connectivity related to apathy outcomes in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- State-Dependent Modulation of a Theta-Responsive Subnetwork by High-Frequency Stimulation of the Ventral Striatum.Neuroscience bulletin · 2026Article
- Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches.Current psychiatry reports · 2026Review
- Mapping the topographic organization of the human zona incerta using diffusion MRI.bioRxiv : the preprint server for biology · 2026Article
- Multimodal Image Guidance in Subthalamic Deep Brain Stimulation for Parkinson's Disease.Annals of neurology · 2026Article
- Associations between altered morphometric inverse divergence networks, choroid plexus volume, and perivascular space network in patients with Parkinson disease: a cross-sectional study.Quantitative imaging in medicine and surgery · 2026Article
- Toward Optimizing Thalamic Deep Brain Stimulation for Cortical Modulation: A Surrogate Brain Approach.bioRxiv : the preprint server for biology · 2026Article
- Article
- Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans.Nature neuroscience · 2026Article
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- White matter microstructural alterations correlate with clinical characteristics in craniocervical dystonia.Neuroradiology · 2026Article
- Age, emotional burden and deep brain stimulation electrode location shape Parkinson's disease quality of life.NPJ digital medicine · 2026Article
- Beyond the Homunculus-SCAN-AMN as a Shared Action-Oriented Neural Substrate across Movement Disorders.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Macroscale Gradient-Informed Neural Oscillation Topography in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Subthalamic segmentations in relation to deep brain stimulation volumes in Parkinson's disease.Acta neurochirurgica · 2026Article
- Targeting based on patient-specific 7 Tesla MRI connectivity analysis improves deep brain stimulation for Parkinson's disease.NPJ Parkinson's disease · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
39 authors at 18 institutions in 9 countries.
Barbara HollunderMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-0104-6927
Jill L OstremMovement Disorders and Neuromodulation Centre, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Ilkem Aysu SahinMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0009-0005-9951-374X
Nanditha RajamaniMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Simón OxenfordMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-2989-3861
Konstantin ButenkoCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Clemens NeudorferCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pablo ReinhardtDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Patricia ZvarovaMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Mircea PolosanUniversité Grenoble Alpes, Grenoble, France.
Harith AkramUnit of Functional Neurosurgery, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-2899-628X
Matteo VissaniDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3908-7620
Chencheng ZhangDepartment of Neurosurgery, Rujin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-4472-4134
Bomin SunDepartment of Neurosurgery, Rujin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-5931-2197
Pavel NavratilDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Martin M ReichDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-9115-5136
Jens VolkmannDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Fang-Cheng YehDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-7946-2173
Juan Carlos BaldermannDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-5851-9268
Till A DembekCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7023-146X
Veerle Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-5274-7929
Eduardo Joaquim Lopes AlhoClinic of Pain and Functional Neurosurgery, São Paulo, Brazil.
Paulo Roberto FranceschiniDepartment of Neurology and Neurosurgery, University of Caxias do Sul, Rio Grande do Sul, Brazil.
Pranav NandaDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Carsten FinkeEinstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-7665-1171
Andrea A KühnMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-4134-9060
Darin D DoughertyDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4691-4353
R Mark RichardsonDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2620-7387
Hagai BergmanEdmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-2402-6673
Mahlon R DeLongDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Alberto MazzoniThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.
Luigi M RomitoParkinson and Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID http://orcid.org/0000-0002-6772-1035
Himanshu TyagiUnit of Functional Neurosurgery, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-4927-4972
Ludvic ZrinzoUnit of Functional Neurosurgery, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0002-6013-4946
Eileen M JoyceUnit of Functional Neurosurgery, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-0469-2844
Stephan ChabardesUniversité Grenoble Alpes, Grenoble, France.
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2733-4003
Ningfei Li *Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. ningfei.li@gmail.com.ORCID http://orcid.org/0000-0003-3315-3591
Andreas Horn *Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. ahorn1@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-0695-6025
Harvard University · USCharité - Universitätsmedizin Berlin · DENational Hospital for Neurology and Neurosurgery · GBBrigham and Women's Hospital · USHumboldt-Universität zu Berlin · DEUniversitätsklinikum Würzburg · DEEinstein Center for Neurosciences Berlin · DEInserm · FRShanghai Jiao Tong University · CNUniversity of Cologne · DECentre for Movement Disorders · CAEmory University · USFondazione IRCCS Istituto Neurologico Carlo Besta · ITHebrew University of Jerusalem · ILScuola Superiore Sant'Anna · ITUniversidade de Caxias do Sul · BRUniversity of California, San Francisco · USUniversity of Pittsburgh · US
Funding
BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5MUsing human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9MToward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9MUsing Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4MMedical Research Council MR/J012009/1NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NINDS NIH HHS R01 NS127892NINDS NIH HHS UM1 NS132358
Abstract
Frontal circuits play a critical role in motor, cognitive and affective processing, and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)functions remains largely elusive. We studied 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregated the frontal cortex into circuits that had become dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to frontal, ranging from interconnections with sensorimotor cortices in dystonia, the primary motor cortex in Tourette's syndrome, the supplementary motor area in Parkinson's disease, to ventromedial prefrontal and anterior cingulate cortices in obsessive-compulsive disorder. Our findings highlight the integration of deep brain stimulation with brain connectomics as a powerful tool to explore couplings between brain structure and functional impairments in the human brain.
Indexed as
Deep Brain StimulationMotor CortexParkinson DiseaseBrainBrain MappingHumans
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.