ArticleSchizophrenia (Heidelberg, Germany)2024
Linking childhood trauma to the psychopathology of schizophrenia: the role of oxytocin.
Article in Schizophrenia (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oxytocin dysfunction in severe mental illnesses following adverse childhood experiences: a systematic review.BMC psychiatry · 2026Pooled it
- The role of plasma oxytocin in early-onset schizophrenia: implications for disease severity and early intervention.BMC psychiatry · 2026Article
- Role of childhood trauma in interoception and alexithymia in schizophrenia.Journal of psychiatric research · 2026Article
- Borderline Personality Disorder or First-Episode Psychosis? Challenges in Assessing Psychotic Features in Early Intervention: A Case Report.Early intervention in psychiatry · 2025Article
- Exposotypes in psychotic disorders.Scientific reports · 2025Article
- Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia.BMC psychiatry · 2025Article
- Psychophysiology of facial emotion recognition in psychopathy dimensions and oxytocin's role: A scoping review.PloS one · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Childhood trauma has been linked to schizophrenia, but underlying biological mechanisms remain elusive. This study explored the potential role of plasma oxytocin as a mediator in the relationship between childhood trauma and the psychopathology of schizophrenia. 160 patients with schizophrenia and 80 age- and sex-matched healthy controls were assessed for childhood trauma experiences using the Childhood Trauma Questionnaire and structured interviews. Psychopathology was evaluated using the Positive and Negative Syndrome Scale and plasma oxytocin levels were measured. Results showed that patients with schizophrenia had lower oxytocin levels and higher childhood trauma scores than healthy controls. There was a significant correlation between childhood trauma scores and psychopathology, with plasma oxytocin levels being inversely associated with psychopathology, except for positive symptoms. Hierarchical regression analysis indicated that both childhood trauma scores and plasma oxytocin levels significantly predicted psychopathology. Plasma oxytocin levels partially mediated the relationship between childhood trauma and schizophrenia psychopathology. This study underscores the potential role of oxytocin in bridging the gap between childhood trauma and schizophrenia.
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Registered trials
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