Evidence map›Paper›PMID 38388530›Full record

ArticleNPJ vaccines2024

No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines.

Ahmet Yalcinkaya, Marco Cavalli, Axel Cederholm, Maribel Aranda-Guillén, Anish Behere, Hedvig Mildner, Tadepally Lakshmikanth, Laura Gonzalez, Constantin Habimana Mugabo, Anette Johnsson and 7 more

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Challenges in the Application of African Swine Fever Vaccines in Asia.Animals : an open access journal from MDPI · 2024
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Ahmet YalcinkayaDepartment of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. ahmet.yalcinkaya@imbim.uu.se.ORCID http://orcid.org/0000-0002-1172-3330
Marco CavalliDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Axel CederholmDepartment of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0009-0006-5973-9637
Maribel Aranda-GuillénCenter for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0050-704X
Anish BehereDepartment of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-2424-3475
Hedvig MildnerDepartment of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0009-0009-6636-2008
Tadepally LakshmikanthDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7256-5770
Laura GonzalezDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Constantin Habimana MugaboDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Anette JohnssonDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Olov EkwallDepartment of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Olle KämpeCenter for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6091-9914
Sophie BensingDepartment of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.
Petter Brodin *Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Pär Hallberg *Department of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Mia Wadelius *Department of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-6368-2622
Nils Landegren *Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. nils.landegren@imbim.uu.se.
Uppsala University · SEKarolinska Institutet · SEKarolinska University Hospital · SEScience for Life Laboratory · SEUniversity of Gothenburg · SE

Funding

Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) KAW 2021.0010_VC-2020-0040Vetenskapsrådet (Swedish Research Council) 2021-03118Vetenskapsrådet (Swedish Research Council) 2021-05450
6 · The paper itself

Abstract

Type I interferons act as gatekeepers against viral infection, and autoantibodies that neutralize these signaling molecules have been associated with COVID-19 severity and adverse reactions to the live-attenuated yellow fever vaccine. On this background, we sought to examine whether autoantibodies against type I interferons were associated with adverse events following COVID-19 vaccination. Our nationwide analysis suggests that type I interferon autoantibodies were not associated with adverse events after mRNA or viral-vector COVID-19 vaccines.

Identifiers

PMID38388530
PMCPMC10883980
OpenAlexW4392036003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.