ArticleMicrobiome2024
Gut microbiota modulation enhances the immune capacity of lizards under climate warming.
Article in Microbiome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Mapping the subgingival HerBiome and HisBiome over the human healthspan.Journal of periodontology · 2026Article
- Gut microbiota as key mediators of animal acclimation to temperature changes: mechanisms and interventions.Applied and environmental microbiology · 2026Review
- How Host Phylogeny, Diet, and Habitat Affect Gut Microbial Diversity in Wild Snakes.Ecology and evolution · 2026Article
- Molecular mechanisms behind the temporal dynamics of LPS-induced inflammatory response in splenic phagocytes of the wall lizard Hemidactylus flaviviridis.The Journal of experimental biology · 2026Article
- Gut yeasts accelerate chill coma recovery in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Fecal Microbiota Transplantation in Animals: Therapeutics, Conservation, and Farming.Microorganisms · 2025Review
- Characteristics of the Gut Microbiota in Different Segments of the Gastrointestinal Tract of Big-Eyed Bamboo Snake (Animals : an open access journal from MDPI · 2025Article
- Metabolic acclimation to warming links unexpected immune activation and sexual dimorphism attenuation in Xenopus tropicalis.Communications biology · 2025Article
- Does the Gut Microbiome of the Insular Lizard Gallotia galloti Reflect Variation in Sex, Environment, and Population Genetic Differentiation?Microbial ecology · 2025Article
- Effects of Periodic Short-Term Heat Stress on Biological Characteristics and Gut Bacteria ofInsects · 2025Article
- Ontogenetic Analysis ofInsects · 2025Article
- Reciprocal translocation experiments reveal gut microbiome plasticity and host specificity in a Qinghai-Xizang Plateau lizard.Zoological research · 2025Article
- Case Report: Oral fecal microbiota transplantation in a Mediterranean spur-thighed tortoise (Frontiers in veterinary science · 2025Article
- Characteristics and dynamic changes of gut microbiota in Mongolian horses and Guizhou horses.Frontiers in microbiology · 2025Article
- Fecal microbiota transplants facilitate post-antibiotic recovery of gut microbiota in cheetahs (Acinonyx jubatus).Communications biology · 2024Article
- Differences in Gut Microbial Composition and Characteristics Among Three Populations of the Bamboo Pitviper (Ecology and evolution · 2024Article
- All roads lead to Rome: the plasticity of gut microbiome drives the extensive adaptation of the Yarkand toad-headed agama (Frontiers in microbiology · 2024Article
- Unlocking the power of short-chain fatty acids in ameliorating intestinal mucosal immunity: a new porcine nutritional approach.Frontiers in cellular and infection microbiology · 2024Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHost-microbial interactions are expected to affect species' adaptability to climate change but have rarely been explored in ectothermic animals. Some studies have shown that short-term warming reduced gut microbial diversity that could hamper host functional performance.
resultsHowever, our longitudinal experiments in semi-natural conditions demonstrated that warming decreased gut microbiota diversity at 2 months, but increased diversity at 13 and 27 months in a desert lizard (Eremias multiocellata). Simultaneously, long-term warming significantly increased the antibacterial activity of serum, immune responses (higher expression of intestinal immune-related genes), and the concentration of short-chain fatty acids (thereby intestinal barrier and immunity) in the lizard. Fecal microbiota transplant experiments further revealed that increased diversity of gut microbiota significantly enhanced antibacterial activity and the immune response of lizards. More specifically, the enhanced immunity is likely due to the higher relative abundance of Bacteroides in warming lizards, given that the bacteria of Bacteroides fragilis regulated IFN-β expression to increase the immune response of lizards under a warming climate.
conclusionsOur study suggests that gut microbiota can help ectotherms cope with climate warming by enhancing host immune response, and highlights the importance of long-term studies on host-microbial interactions and their biological impacts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.