ArticleBMC infectious diseases2024
Mortality and associated factors among people living with HIV admitted at a tertiary-care hospital in Uganda: a cross-sectional study.
Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cause of Death and Risk of Death for People Living With HIV Admitted to Hospital: A Systematic Review and Meta-Analysis.Journal of the International AIDS Society · 2026Pooled it
- High two-month mortality in Gabonese adults with and without tuberculosis: A prospective cohort study of patients with presumed pulmonary tuberculosis.IJID regions · 2026Article
- High risk of COVID-19 mortality in people living with advanced HIV disease in South Africa: A retrospective cohort study.Medicine · 2026Article
- Descriptive epidemiology of opportunistic infections among patients with advanced HIV disease in Kinshasa, Democratic Republic of Congo.BMC infectious diseases · 2026Article
- Article
- Persistent pneumococcal colonisation in antiretroviral-treated HIV infection is associated with nasal inflammation.Nature communications · 2025Article
- Mortality and associated factors among PLHIV admitted in selected hospitals in Ethiopia: A Cross-sectional Study.BMC infectious diseases · 2025Article
- Impact of an optimized care model for advanced HIV disease: a non-randomized cluster study in Malawi.BMC public health · 2025Article
- Review
- Interventions to Support People With HIV Following Hospital Discharge: A Systematic Review.Open forum infectious diseases · 2025Article
- Global prevalence of advanced HIV disease in healthcare settings: a rapid review.Journal of the International AIDS Society · 2025Review
- HIV multidrug class resistance prediction with a time sliding anchor approach.Bioinformatics advances · 2025Article
- Accuracy of nursing diagnoses of hospitalized people with HIV: implications for care.Revista brasileira de enfermagem · 2025Article
- Antiretroviral treatment outcomes and survival pattern of people living with HIV in Bauchi State, Nigeria.PloS one · 2025Article
- Assessment of Awareness and Acceptability of Hospital Autopsy Among People Living with HIV and Their Caregivers in Northern Uganda.HIV/AIDS (Auckland, N.Z.) · 2025Article
- Metagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda.PLoS neglected tropical diseases · 2024Article
- 'Not taking medications and taking medication, it was the same thing:' perspectives of antiretroviral therapy among people hospitalised with advanced HIV disease.BMC infectious diseases · 2024Article
- Advanced HIV disease and its predictors among newly diagnosed PLHIV in the Gedeo zone, southern Ethiopia.PloS one · 2024Article
- Inability-to-walk-unaided-a single WHO danger sign predicts in-hospital mortality in people with HIV under routine care conditions in a low-resource setting.Therapeutic advances in infectious diseaseArticle
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10 authors.
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Abstract
backgroundHospital admission outcomes for people living with HIV (PLHIV) in resource-limited settings are understudied. We describe in-hospital mortality and associated clinical-demographic factors among PLHIV admitted at a tertiary-level public hospital in Uganda.
methodsWe performed a cross-sectional analysis of routinely collected data for PLHIV admitted at Kiruddu National Referral Hospital between March 2020 and March 2023. We estimated the proportion of PLHIV who had died during hospitalization and performed logistic regression modelling to identify predictors of mortality.
resultsOf the 5,827 hospitalized PLHIV, the median age was 39 years (interquartile range [IQR] 31-49) and 3,293 (56.51%) were female. The median CD4 + cell count was 109 cells/µL (IQR 25-343). At admission, 3,710 (63.67%) were active on antiretroviral therapy (ART); 1,144 (19.63%) had interrupted ART > 3 months and 973 (16.70%) were ART naïve. In-hospital mortality was 26% (1,524) with a median time-to-death of 3 days (IQR 1-7). Factors associated with mortality (with adjusted odds ratios) included ART interruption, 1.33, 95% confidence intervals (CI) 1.13-1.57, p 0.001; CD4 + counts ≤ 200 cells/µL 1.59, 95%CI 1.33-1.91, p < 0.001; undocumented CD4 + cell count status 2.08, 95%CI 1.73-2.50, p < 0.001; impaired function status 7.35, 95%CI 6.42-8.41, p < 0.001; COVID-19 1.70, 95%CI 1.22-2.37, p 0.002; liver disease 1.77, 95%CI 1.36-2.30, p < 0.001; co-infections 1.53, 95%CI 1.32-1.78, p < 0.001; home address > 20 km from hospital 1.23, 95%CI 1.04-1.46, p 0.014; hospital readmission 0.7, 95%CI 0.56-0.88, p 0.002; chronic lung disease 0.62, 95%CI 0.41-0.92, p 0.019; and neurologic disease 0.46, 95%CI 0.32-0.68, p < 0.001.
conclusionOne in four admitted PLHIV die during hospitalization. Identification of risk factors (such as ART interruption, function impairment, low/undocumented CD4 + cell count), early diagnosis and treatment of co-infections and liver disease could improve outcomes.
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