Evidence map›Paper›PMID 38387984›Full record

Observational studyBMJ open2024

Mortality and health-related quality of life in older adults with long-term use of opioids, z-hypnotics or benzodiazepines: a prospective observational study at 5 years follow-up.

Maria Torheim Bjelkarøy, Tone Breines Simonsen, Tahreem Ghazal Siddiqui, Socheat Cheng, Ramune Grambaite, Jūratė Šaltytė Benth, Christofer Lundqvist

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03162081 (Medication Misuse and Dependence in Elderly Patients), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03162081 active not recruitingnot on this map

Medication Misuse and Dependence in Elderly Patients

Typeobservational_patient_registrySponsorUniversity Hospital, AkershusRan2017 to 2024Enrolled500ConditionsMild Cognitive Impairment, Elderly, Substance-Related DisordersArmsSubstance misuse screening, EQ-5D, Impulsivity screening, Cognitive screening, Functional tests
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Maria Torheim BjelkarøyAkershus University Hospital, Lorenskog, Norway matobj@ahus.no.ORCID 0000-0002-0557-1457
Tone Breines SimonsenAkershus University Hospital, Lorenskog, Norway.
Tahreem Ghazal SiddiquiAkershus University Hospital, Lorenskog, Norway.
Socheat ChengAkershus University Hospital, Lorenskog, Norway.ORCID 0000-0003-2277-7585
Ramune GrambaiteAkershus University Hospital, Lorenskog, Norway.
Jūratė Šaltytė BenthAkershus University Hospital, Lorenskog, Norway.
Christofer LundqvistAkershus University Hospital, Lorenskog, Norway.
University of Oslo · NOAkershus University Hospital · NONorwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDisease and medication use in older age is a consequence of age-related declining health. Multimorbidity followed by polypharmacy is common. Central nervous system depressing (CNSD) drugs such as opioids, benzodiazepines and z-hypnotics are not recommended for long-term use in older adults but are in use by many. We aimed to assess mortality and change in health-related quality of life (HRQoL) in older adults with long-term use of CNSDs.

methodA prospective observational study was conducted at Akershus University Hospital, Norway, 2017-2019, with follow-up in 2021-2022, including 246 participants aged 65-90. At 5-year follow-up, 78 (32%) participants had passed away. Mortality data were collected from patient electronic health records. Of the surviving 168 (68%), we collected further follow-up data from 38 (16%) participants. Follow-up included demographic and clinical data. The EuroQuol Group EQ-5D-5L questionnaire was used to measure HRQoL. Analysis include Cox regression model for survival data and linear mixed model for change in HRQoL over time.

resultsAt follow-up, 78 (31.7%) were deceased. Mean survival time was 3.3 years. Total time for survival data was 4.7 years. Mortality was higher among participants with long-term use of CNSD (HR 1.9 95% CI (1.2 to 3.2), p=0.01). The multivariable analysis found being older (HR 1.1 95% CI (1.0 to 1.1), p=0.020) and male sex (HR 2.1 95% CI (1.2 to 3.5), p=0.008) to be associated with increased risk of mortality. According to the linear mixed model (n=38), there was no significant difference between surviving users and non-users in change in HRQoL EQ-5D-5L index from baseline to follow-up.

conclusionMortality was higher for long-term users of CNSDs at 5-year follow-up. Being older and male sex were associated with mortality. Among survivors, there was no significant difference between the groups in change of HRQoL over time. TRIAL REGISTRATION NUMBER: NCT03162081; 22 May 2017.

Indexed as

BenzodiazepinesHypnotics and SedativesAgedAnalgesics, OpioidFollow-Up StudiesHumansMaleProspective StudiesQuality of LifeSurveys and QuestionnairesAnalgesics, OpioidBenzodiazepinesHypnotics and Sedativesgeriatric medicinemortalityquality of life

Identifiers

PMID38387984
PMCPMC10882342
OpenAlexW4392085582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.