Evidence map›Paper›PMID 38387218›Full record

ArticlePsychoneuroendocrinology2024

Sex-specific associations between placental corticotropin releasing hormone and problem behaviors in childhood.

Emily S Barrett, Alexandra Sullivan, Tomomi Workman, Yuhong Zhang, Christine T Loftus, Adam A Szpiro, Alison Paquette, James W MacDonald, Michael Coccia, Roger Smith and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 2 countries.

Emily S BarrettDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. Electronic address: Emily.barrett@eohsi.rutgers.edu.
Alexandra SullivanCenter for Health and Community, University of California, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Tomomi WorkmanDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Yuhong ZhangDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Christine T LoftusDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Adam A SzpiroDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Alison PaquetteDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA.
James W MacDonaldDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Michael CocciaCenter for Health and Community, University of California, San Francisco, CA, USA.
Roger SmithMothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Maria BowmanMothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Alicia SmithDepartment of Gynecology and Obstetrics, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, USA.
Karen DerefinkoDepartment of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Ruby H N NguyenDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Qi ZhaoDepartment of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Sheela SathyanarayanaDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Catherine KarrDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Kaja Z LeWinnDepartment of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Nicole R BushCenter for Health and Community, University of California, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
University of Washington · USUniversity of California, San Francisco · USHunter Medical Research Institute · AUUniversity of Tennessee Health Science Center · USEmory University · USInstitute for Community Health · USRutgers, The State University of New Jersey · USUniversity of Minnesota · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Emily S Barrett · 1988 to 2026
$47.4M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1M
ECHO in Agricultural Washington and Rural Environments (ECHO AWARE)UG3OD035528 · OD · UNIVERSITY OF WASHINGTON · PI KARR, CATHERINE J · 2023 to 2024
$2.4M
NIEHS NIH HHS P30 ES005022NIH HHS UG3 OD023271NIH HHS UG3 OD035528NIH HHS UH3 OD023271
6 · The paper itself

Abstract

Placental corticotropin-releasing hormone (pCRH) is a neuroactive peptide produced in high concentrations in mid-late pregnancy, during key periods of fetal brain development. Some evidence suggests that higher pCRH exposure during gestation is associated with adverse neurodevelopment, particularly in female offspring. In 858 mother-child dyads from the sociodemographically diverse CANDLE cohort (Memphis, TN), we examined: (1) the slope of pCRH rise in mid-late pregnancy and (2) estimated pCRH at delivery as a measure of cumulative prenatal exposure. When children were 4 years-old, mothers reported on problem behaviors using the Child Behavior Checklist (CBCL) and cognitive performance was assessed by trained psychologists using the Stanford-Binet Intelligence Scales. We fitted linear regression models examining pCRH in relation to behavioral and cognitive performance measures, adjusting for covariates. Using interaction models, we evaluated whether associations differed by fetal sex, breastfeeding, and postnatal neighborhood opportunity. In the full cohort, log-transformed pCRH measures were not associated with outcomes; however, we observed sex differences in some models (interaction p-values≤0.01). In male offspring, an interquartile (IQR) increase in pCRH slope (but not estimated pCRH at delivery), was positively associated with raw Total (β=3.06, 95%CI: 0.40, 5.72), Internalizing (β=0.89, 95%CI: 0.03, 1.76), and Externalizing (β=1.25, 95%CI: 0.27, 2.22) Problem scores, whereas, in females, all associations were negative (Total Problems: β=-1.99, 95%CI: -3.89, -0.09; Internalizing: β=-0.82, 95%CI: -1.42, -0.23; Externalizing: β=-0.56, 95%CI: -1.34, 0.22). No associations with cognitive performance were observed nor did we observe moderation by breastfeeding or postnatal neighborhood opportunity. Our results provide further evidence that prenatal pCRH exposure may impact subsequent child behavior in sex-specific ways, however in contrast to prior studies suggesting adverse impacts in females, steeper mid-gestation pCRH rise was associated with more problem behaviors in males, but fewer in females.

Indexed as

Prenatal Exposure Delayed EffectsProblem BehaviorChild, PreschoolCorticotropin-Releasing HormoneFemaleFetal DevelopmentHumansMalePlacentaPregnancyPrenatal CareCorticotropin-Releasing HormoneChild behaviorCRHDOHaDNeurodevelopmentPlacental corticotropin releasing hormoneSex differences

Identifiers

PMID38387218
PMCPMC11924197
OpenAlexW4391887732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.