ReviewBrain : a journal of neurology2024
Limitation of life sustaining therapy in disorders of consciousness: ethics and practice.
Review in Brain : a journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Shared Decision-Making for Patients with Stroke in Neurocritical Care: A Qualitative Meta-Synthesis.Neurocritical care · 2025Pooled it
- Common Consent Elements for Research Involving Persons with Disorders of Consciousness (CCE-DOC).Neurocritical care · 2026Article
- From fMRI to Family Meeting: Clinician and Family Perspectives on Neurotechnology-Informed Shared Decision-Making in Disorders of Consciousness.Neurocritical care · 2026Article
- Advances in local field potential research in prolonged disorders of consciousness: a narrative review.Chinese neurosurgical journal · 2026Review
- Concorde Syndrome in the Treatment of People with Cancer: Validation of a Measurement Instrument.International journal of behavioral medicine · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Article
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
- Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable.Intensive care medicine · 2026Review
- Healthcare professionals' experiences of participating in withdrawing life-sustaining treatment decisions in a Chinese intensive care unit: a qualitative study.BMC medical ethics · 2025Article
- Detecting Awareness in the Intensive Care Unit Using Functional Near-Infrared Spectroscopy.Annals of neurology · 2025Article
- Withdrawal of life-sustaining therapies after cardiac arrest.Current opinion in critical care · 2025Review
- Early Detection of Covert Consciousness With Functional Near-Infrared Spectroscopy.Annals of neurology · 2025Article
- Emerging issues in the management of patients with disorders of consciousness.Journal of neurology · 2025Review
- Functional neuroimaging in disorders of consciousness: towards clinical implementation.Brain : a journal of neurology · 2025Review
- Stimulation intensities influence the effects of spinal cord stimulation in disorders of consciousness: an fNIRS study.Neurophotonics · 2025Article
- Ethically Translating Advanced Neurotechnologies for Disorders of Consciousness: A Survey of Clinicians' Perspectives.Neurocritical care · 2025Article
- Evaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy.Frontiers in neurology · 2025Article
- Clinical and ethical challenges in decision-making for patients with disorders of consciousness and locked-in syndrome from Chinese neurologists' perspectives.Therapeutic advances in neurological disorders · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Clinical conversations surrounding the continuation or limitation of life-sustaining therapies (LLST) are both challenging and tragically necessary for patients with disorders of consciousness (DoC) following severe brain injury. Divergent cultural, philosophical and religious perspectives contribute to vast heterogeneity in clinical approaches to LLST-as reflected in regional differences and inter-clinician variability. Here we provide an ethical analysis of factors that inform LLST decisions among patients with DoC. We begin by introducing the clinical and ethical challenge and clarifying the distinction between withdrawing and withholding life-sustaining therapy. We then describe relevant factors that influence LLST decision-making including diagnostic and prognostic uncertainty, perception of pain, defining a 'good' outcome, and the role of clinicians. In concluding sections, we explore global variation in LLST practices as they pertain to patients with DoC and examine the impact of cultural and religious perspectives on approaches to LLST. Understanding and respecting the cultural and religious perspectives of patients and surrogates is essential to protecting patient autonomy and advancing goal-concordant care during critical moments of medical decision-making involving patients with DoC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.