Evidence map›Paper›PMID 38386752›Full record

ArticleScience (New York, N.Y.)2024

Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features.

Carla Hoge, Marc de Manuel, Mohamed Mahgoub, Naima Okami, Zachary Fuller, Shreya Banerjee, Zachary Baker, Morgan McNulty, Peter Andolfatto, Todd S Macfarlan and 3 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. On the origin of PRDM9-guided recombination hotspots.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Evolution of genome-wide barriers to gene flow during complex speciation in rattlesnakes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Why recombination hotspots?PLoS genetics · 2026
    Review
  8. Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Meiotic Recombination in Teleosts.Advances in experimental medicine and biology · 2026
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Carla HogeDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0001-9798-9684
Marc de ManuelDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0002-1245-0127
Mohamed MahgoubThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2687-7874
Naima OkamiDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Zachary FullerDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0003-4765-9227
Shreya BanerjeeDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1210-2162
Zachary BakerDepartment of Systems Biology, Columbia University, New York, NY, USA.ORCID 0000-0002-1540-0731
Morgan McNultyDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Peter AndolfattoDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0003-3393-4574
Todd S MacfarlanThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2495-9809
Molly SchumerDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2075-5668
Athanasia C TzikaLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-0831-5221
Molly PrzeworskiDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0002-5369-9009
Columbia University · USNational Institutes of Health · USHoward Hughes Medical Institute · USStanford University · USUniversity of Geneva · CH

Funding

Mechanisms of Mammalian Epigenome ReprogrammingZIAHD008933 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MACFARLAN, TODD SCOTT · 2013 to 2025
$19.1M
Recombination rate variation and evolution in vertebratesR01GM083098 · NIGMS · UNIVERSITY OF CHICAGO · PI PRZEWORSKI, MOLLY F · 2007 to 2024
$4.6M
The population genomics of hybridization: from genetic incompatibilities to genome evolutionR35GM133774 · NIGMS · STANFORD UNIVERSITY · PI Molly Schumer · 2019 to 2026
$3.3M
Intramural NIH HHS ZIA HD008933NIGMS NIH HHS R01 GM083098NIGMS NIH HHS R35 GM133774
6 · The paper itself

Abstract

In some mammals, notably humans, recombination occurs almost exclusively where the protein PRDM9 binds, whereas in vertebrates lacking an intact

Indexed as

ColubridaeHistone-Lysine N-MethyltransferaseRecombination, GeneticAnimalsPromoter Regions, GeneticHistone-Lysine N-MethyltransferasePRDM9 protein, human

Identifiers

PMID38386752
PMCPMC13276982
OpenAlexW4392028010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.