Evidence map›Paper›PMID 38386639›Full record

ArticlePLoS biology2024

Knowns and unknowns about the neurobiology of stuttering.

Nicole E Neef, Soo-Eun Chang

Open access · goldAbstract read
In one paragraph

Article in PLoS biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
30.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 48 citations in OpenAlex.

  1. Developmental stuttering with common and complex phenotypes.Developmental medicine and child neurology · 2026
    Article
  2. Article
  3. Article
  4. Neural subtypes in developmental stuttering.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. A stuttering-associatedbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. An active inference account of stuttering behavior.Frontiers in human neuroscience · 2025
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Nicole E NeefInstitute for Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0003-2414-7595
Soo-Eun ChangDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, United States of America.
Ewha Womans University · KRUniversitätsmedizin Göttingen · DE

Funding

Sexual dimorphism of neural development underlying childhood stutteringR01DC011277 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Soo-Eun Chang · 2010 to 2026
$8.2M
Neural oscillations underlying speech perception and production in childhood stutteringR01DC018283 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHANG, SOO-EUN · 2020 to 2024
$2.3M
Imaging genetics study of twins who stutterR21DC015312 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHANG, SOO-EUN · 2017 to 2018
$440k
NIDCD NIH HHS R01 DC011277NIDCD NIH HHS R01 DC018283NIDCD NIH HHS R21 DC015312
6 · The paper itself

Abstract

Stuttering occurs in early childhood during a dynamic phase of brain and behavioral development. The latest studies examining children at ages close to this critical developmental period have identified early brain alterations that are most likely linked to stuttering, while spontaneous recovery appears related to increased inter-area connectivity. By contrast, therapy-driven improvement in adults is associated with a functional reorganization within and beyond the speech network. The etiology of stuttering, however, remains enigmatic. This Unsolved Mystery highlights critical questions and points to neuroimaging findings that could inspire future research to uncover how genetics, interacting neural hierarchies, social context, and reward circuitry contribute to the many facets of stuttering.

Indexed as

StutteringAdultBrainCase-Control StudiesChildChild, PreschoolHumansNeuroimagingSpeech

Identifiers

PMID38386639
PMCPMC10883586
OpenAlexW4392029951

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.