Evidence map›Paper›PMID 38386630›Full record

ArticleJournal of the American Chemical Society2024

Biosynthesis of Cytosporones in Leotiomycetous Filamentous Fungi.

Li Li, Weimao Zhong, Hang Liu, Patricia Espinosa-Artiles, Ya-Ming Xu, Chen Wang, Jose Manuel Verdugo Robles, Tiago Antunes Paz, Marielle Cascaes Inácio, Fusheng Chen and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 4 countries.

Li LiSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.ORCID 0000-0002-5462-9416
Weimao ZhongSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.
Hang LiuSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.ORCID 0009-0003-2719-4001
Patricia Espinosa-ArtilesSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.
Ya-Ming XuSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.
Chen WangSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.
Jose Manuel Verdugo RoblesSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.ORCID 0009-0009-4074-4614
Tiago Antunes PazSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, Brazil.ORCID 0000-0001-6193-7321
Marielle Cascaes InácioSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.ORCID 0000-0002-9570-8241
Fusheng ChenSchool of Life Sciences, Guizhou Normal University, Guiyang 550025, P.R. China.ORCID 0000-0001-8525-4154
Yuquan XuBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.ORCID 0000-0002-1363-6476
A A Leslie GunatilakaSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.ORCID 0000-0001-9663-3600
István MolnárSouthwest Center for Natural Products Research, University of Arizona, Tucson, Arizona 85719, United States.ORCID 0000-0002-3627-0454
University of Arizona · USGuizhou Normal University · CN

Funding

Combinatorial biosynthesis of fungal benzenediol lactone polyketidesR01GM114418 · NIGMS · UNIVERSITY OF ARIZONA · PI MOLNAR, ISTVAN · 2016 to 2019
$1.4M
NIGMS NIH HHS R01 GM114418
6 · The paper itself

Abstract

Polyketides with the isochroman-3-one pharmacophore are rare among fungal natural products as their biosynthesis requires an unorthodox S-type aromatic ring cyclization. Genome mining uncovered a conserved gene cluster in select leotiomycetous fungi that encodes the biosynthesis of cytosporones, including isochroman-3-one congeners. Combinatorial biosynthesis in total biosynthetic and biocatalytic formats in

Indexed as

Biological ProductsPolyketidesFungiPolyketide SynthasesSaccharomyces cerevisiaeBiological ProductsPolyketidesPolyketide Synthases

Identifiers

PMID38386630
PMCPMC11106036
OpenAlexW4392079818

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.