Evidence map›Paper›PMID 38386249›Full record

ArticleSleep & breathing = Schlaf & Atmung2024

Association between sleep apnea-specific hypoxic burden and severity of coronary artery disease.

Hehe Zhang, Honghong Liu, Yuanni Jiao, Jing Zhang, Naima Covassin, Mu Wang, Yun Lin, Jiang Xie

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hehe ZhangDepartment of Respiratory and Critical Medicine, Beijing Anzhen Hospital, Capital Medical University, #2 An Zhen Road, Beijing, 100029, China.
Honghong LiuDepartment of Cardiovascular Medicine, Beijing Anzhen Hospital, Capital Medical University, #2 An Zhen Road, Beijing, 100029, China.
Yuanni JiaoDepartment of Respiratory and Critical Medicine, Beijing Anzhen Hospital, Capital Medical University, #2 An Zhen Road, Beijing, 100029, China.
Jing ZhangInstitute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Naima CovassinDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USA.
Mu WangSchool of Aerospace Engineering, Tsinghua University, Beijing, 100084, China.
Yun LinDepartment of Cardiovascular Medicine, Beijing Anzhen Hospital, Capital Medical University, #2 An Zhen Road, Beijing, 100029, China. linyun1861@hotmail.com.
Jiang XieDepartment of Respiratory and Critical Medicine, Beijing Anzhen Hospital, Capital Medical University, #2 An Zhen Road, Beijing, 100029, China. frank782008@aliyun.com.ORCID 0000-0002-1737-9083
Capital Medical University · CNMayo Clinic in Arizona · USTsinghua University · CN

Funding

National Natural Science Foundation of China 81970079National Natural Science Foundation of China 82270099
6 · The paper itself

Abstract

purposeSleep apnea-specific hypoxic burden (SASHB) is a polysomnographic metric that comprehensively measures the degree of nocturnal desaturation caused by obstructive sleep apnea. This research was conducted to elucidate the relationship between SASHB and coronary artery disease (CAD) severity.

methodsWe carried out a prospective study of hospitalized patients with CAD of unstable angina who were expected to undergo invasive coronary angiography at Beijing Anzhen Hospital from February to September 2023. SASHB values were calculated using a self-programmed C +  + program. Multivariable logistic regression analysis was applied to identify the association between SASHB and the prevalence of severe CAD, documented by the Gensini Score, and the SYNTAX (Synergy between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) Score.

resultsThis study enrolled 137 patients with a median age of 59 years, 96 (70.1%) of whom were male. A total of 125 (91.2%) patients had coronary stenosis of ≥ 50% in at least one location. Patients with a high SASHB of ≥ 18% min/h had a significantly higher Gensini Score (32.0 vs. 18.5, P = 0.002) and SYNTAX Score (14.0 vs. 7.0, P = 0.002) than those with a low SASHB. After adjusting for multiple covariates, a high SASHB was significantly associated with the prevalence of severe CAD, determined by a Gensini Score ≥ 21 (OR 2.67, P = 0.008) or a SYNTAX Score > 22 (OR 4.03, P = 0.016).

conclusionOur findings revealed a robust and independent association between SASHB and CAD severity in patients with unstable angina, highlighting the potential value of SASHB as a predictor of risk and a target for interventions aimed at preventing cardiovascular diseases.

trial registrationChinese Clinical Trial Registry No. ChiCTR2300067991 on February 2, 2023.

Indexed as

Coronary Artery DiseaseHypoxiaSeverity of Illness IndexAgedCoronary AngiographyFemaleHumansMaleMiddle AgedPolysomnographyProspective StudiesSleep Apnea, ObstructiveCoronary artery diseaseGensini ScoreObstructive sleep apneaSleep apnea-specific hypoxic burdenSYNTAX Score

Identifiers

PMID38386249
PMCPMC11196324
OpenAlexW4392040903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.