Evidence map›Paper›PMID 38386045›Full record

ArticlePflugers Archiv : European journal of physiology2024

A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects.

Catharina J Küng, Arezoo Daryadel, Rocio Fuente, Betül Haykir, Martin Hrabĕ de Angelis, Nati Hernando, Isabel Rubio-Aliaga, Carsten A Wagner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Updates on renal phosphate transport.Current opinion in nephrology and hypertension · 2025
    Review
  4. An activating calcium-sensing receptor variant with biased signaling reveals a critical residue for Gα11 coupling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Catharina J KüngInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Arezoo DaryadelInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Rocio FuenteInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Betül HaykirInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Martin Hrabĕ de AngelisInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Nati HernandoInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Isabel Rubio-AliagaInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
Carsten A WagnerInstitute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. Wagnerca@access.uzh.ch.ORCID 0000-0002-9874-8898
University of Zurich · CHHelmholtz Zentrum München · DEUniversidad de Oviedo · ESZHAW Zurich University of Applied Sciences · CH

Funding

INFRAFRONTIER 01KX1012Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 176125
6 · The paper itself

Abstract

The Calcium-sensing receptor (CaSR) senses extracellular calcium, regulates parathyroid hormone (PTH) secretion, and has additional functions in various organs related to systemic and local calcium and mineral homeostasis. Familial hypocalciuric hypercalcemia type I (FHH1) is caused by heterozygous loss-of-function mutations in the CaSR gene, and is characterized by the combination of hypercalcemia, hypocalciuria, normal to elevated PTH, and facultatively hypermagnesemia and mild bone mineralization defects. To date, only heterozygous Casr null mice have been available as model for FHH1. Here we present a novel mouse FHH1 model identified in a large ENU-screen that carries an c.2579 T > A (p.Ile859Asn) variant in the Casr gene (Casr

Indexed as

HypercalcemiaParathyroid HormoneReceptors, Calcium-SensingAnimalsCalciumDisease Models, AnimalMaleMiceMice, Inbred C57BLCalciumCASR protein, mouseParathyroid HormonePth protein, mouseReceptors, Calcium-SensingBoneCalcium-sensing receptorFibroblast growth factor 23KidneyMouse modelParathyroid hormone

Identifiers

PMID38386045
PMCPMC11033242
OpenAlexW4392036554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.