Evidence map›Paper›PMID 38386022›Full record

ArticlePediatric radiology2024

Pituitary gland height evaluated with magnetic resonance imaging in premature twins: the impact of growth and sex.

Maria I Argyropoulou, Vasileios Xydis, Loukas G Astrakas, Aikaterini Drougia, Effrosyni I Styliara, Dimitrios-Nikiforos Kiortsis, Vasileios Giapros, Christina Kanaka-Gantenbein

Abstract readTwin Study
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maria I ArgyropoulouDepartment of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece. margyrop@uoi.gr.ORCID 0000-0001-7236-3706
Vasileios XydisDepartment of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece.
Loukas G AstrakasDepartment of Medical Physics, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Aikaterini DrougiaNeonatal Intensive Care Unit, Child Health Department, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Effrosyni I StyliaraDepartment of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece.
Dimitrios-Nikiforos KiortsisDepartment of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece.
Vasileios GiaprosNeonatal Intensive Care Unit, Child Health Department, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Christina Kanaka-GantenbeinDivision of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece.
University of Ioannina · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPituitary gland height reflects secretory activity of the hypothalamo-pituitary axis.

objectiveTo assess the cumulative impact of fetal growth and sex on pituitary gland height in premature twins, dissociated from prematurity. MATERIALS AND

methodsA retrospective study was conducted, assessing the pituitary gland height in 63 pairs of preterm twins, measured from T1-weighted magnetic resonance imaging (MRI). Auxological parameters, including body weight, body length, and head circumference, at birth and at the time of MRI, were used as proxies for fetal and postnatal growth, respectively. The study population was divided into two groups, using corrected age at around term equivalent as the cutoff point. Statistical analysis was performed using mixed-effects linear regression models.

resultsWhen pituitary gland height was evaluated at around term equivalent, a greater pituitary gland height, suggesting a more immature hypothamo-pituitary axis, was associated with the twin exhibiting lower auxological data at birth. The same association was observed when body weight and length at MRI were used as covariants. In the group evaluated after term equivalent, a smaller pituitary gland height, suggesting a more mature hypothamo-pituitary axis, was associated with male sex. This difference was observed in twin pairs with higher average body weight at birth, and in babies exhibiting higher auxological data at MRI.

conclusionAfter isolating the effect of prematurity, at around term equivalent, pituitary gland height reflects the cumulative impact of fetal growth on the hypothalamo-pituitary axis. Subsequently, pituitary gland height shows effects of sex and of fetal and postnatal growth.

Indexed as

Infant, PrematureMagnetic Resonance ImagingPituitary GlandFemaleHumansInfant, NewbornMaleOrgan SizeRetrospective StudiesSex FactorsTwinsBirth weightGestational ageInfantMagnetic resonance imagingNewbornPituitary gland

Identifiers

PMID38386022
OpenAlexW4392057577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.