Evidence map›Paper›PMID 38385738›Full record

ArticleMicrobiology spectrum2024

Mapping niche-specific two-component system requirements in uropathogenic

John R Brannon, Seth A Reasoner, Tomas A Bermudez, Sarah L Comer, Michelle A Wiebe, Taryn L Dunigan, Connor J Beebout, Tamia Ross, Adebisi Bamidele, Maria Hadjifrangiskou

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

John R Brannon *Department of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Seth A Reasoner *Department of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-7791-1641
Tomas A Bermudez *Department of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sarah L ComerDepartment of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-2530-9840
Michelle A WiebeDepartment of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Taryn L DuniganDepartment of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Connor J BeeboutDepartment of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Tamia RossDepartment of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Adebisi BamideleDepartment of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Maria HadjifrangiskouDepartment of Pathology, Microbiology and Immunology, Division of Molecular Pathogenesis, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-4249-8997
Vanderbilt University Medical Center · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM007569 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 1985 to 2026
$12.4M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
How E. coli Acid Response Mechanisms Breach Colonization Resistance in the VaginaR01AI168468 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Maria Hadjifrangiskou · 2022 to 2026
$2.9M
Two-component system interactions as uropathogenic Escherichia coli drug targetsR01AI107052 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HADJIFRANGISKOU, MARIA · 2015 to 2019
$1.9M
The Vanderbilt Urologic Infection Repository, a Resource for Personalized Clinical DiscoveryP20DK123967 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAYTON, DOUGLASS BROOKS, HADJIFRANGISKOU, MARIA · 2019 to 2020
$680k
Copper Sensing in Uropathogenic Escherichia coliF30AI169748 · NIAID · VANDERBILT UNIVERSITY · PI Seth A Reasoner · 2023 to 2026
$156k
The role of cytochrome bd in uropathogenic Escherichia coli pathogenesisF30AI150077 · NIAID · VANDERBILT UNIVERSITY · PI BEEBOUT, CONNOR JAMES · 2020 to 2022
$125k
NIAID NIH HHS F30 AI150077NIAID NIH HHS F30 AI169748NIAID NIH HHS R01 AI107052NIAID NIH HHS R01 AI168468NIDDK NIH HHS P20 DK123967NIDDK NIH HHS P30 DK020593NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM007569NIGMS NIH HHS T32 GM152284
6 · The paper itself

Abstract

Sensory systems allow pathogens to differentiate between different niches and respond to stimuli within them. A major mechanism through which bacteria sense and respond to stimuli in their surroundings is two-component systems (TCSs). TCSs allow for the detection of multiple stimuli to lead to a highly controlled and rapid change in gene expression. Here, we provide a comprehensive list of TCSs important for the pathogenesis of uropathogenic

Indexed as

Escherichia coli InfectionsEscherichia coli ProteinsUrinary TractUrinary Tract InfectionsUropathogenic Escherichia coliFemaleHumansUrinary BladderEscherichia coli Proteinssignal transductiontwo-component systemsUPECUTI

Identifiers

PMID38385738
PMCPMC10986536
OpenAlexW4392044897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.