Evidence map›Paper›PMID 38385597›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2024

Self-recognition through Dectin-1 exacerbates liver inflammation.

Shota Torigoe, Douglas W Lowman, Toshihiko Sugiki, David L Williams, Sho Yamasaki

Open access · bronzeAbstract read
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Frontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Shota TorigoeLaboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0002-4884-3686
Douglas W LowmanDepartment of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Toshihiko SugikiLaboratory of Molecular Biophysics, Institute for Protein Research, Osaka University, Osaka, Japan.
David L WilliamsDepartment of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Sho YamasakiLaboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
East Tennessee State University · USKyushu University · JPNational Institute of Infectious Diseases · JPProtein Research Foundation · JP

Funding

Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6M
Innate Immunity and Cardiovascular Function in SepsisR01GM083016 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU, WILLIAMS, DAVID L. · 2009 to 2021
$3.8M
Development of an alpha-1 phosphate mannan vaccine against the emerging fungal pathogen Candida auris.R21AI173607 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI WILLIAMS, DAVID L. · 2023 to 2024
$413k
NIAID NIH HHS R21 AI173607NIGMS NIH HHS R01 GM083016NIGMS NIH HHS R01 GM119197NIH HHS R01GM083016NIH HHS R01GM119197
6 · The paper itself

Abstract

Dectin-1 is a well-characterized C-type lectin receptor involved in anti-fungal immunity through the recognition of polysaccharides; however, molecular mechanisms and outcomes initiated through self-recognition have not been fully understood. Here, we purified a water-soluble fraction from mouse liver that acts as a Dectin-1 agonist. To address the physiological relevance of this recognition, we utilized sterile liver inflammation models. The CCl

Indexed as

HepatitisLectins, C-TypeNon-alcoholic Fatty Liver DiseaseAnimalsDectin-1InflammationMiceMice, Inbred C57BLWaterClec7a protein, mouseDectin-1Lectins, C-TypeWaterDectin‐1hydrophilic agonistNASHself‐recognitionsterile hepatitis

Identifiers

PMID38385597
PMCPMC11000461
OpenAlexW4392046002

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.