Evidence map›Paper›PMID 38385332›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2024

Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an

Xin Gan, Yuna Wu, Min Zhu, Bo Liu, Miaomiao Kong, Zixuan Xi, Ke Li, Haibao Wang, Tiande Su, Jiali Yao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xin GanThe Second Affiliated Hospital and Yuying Children's Hospital of the Wenzhou Medical University, Wenzhou, China.
Yuna WuThe Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, China.
Min ZhuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Bo LiuThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Miaomiao KongThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zixuan XiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ke LiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Haibao WangMunicipal Hospital Affiliated to Taizhou University, Taizhou, China.
Tiande SuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Jiali YaoSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Fatehi KhushafahSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Baozhu YiThe Second Affiliated Hospital and Yuying Children's Hospital of the Wenzhou Medical University, Wenzhou, China.
Jiabing WangMunicipal Hospital Affiliated to Taizhou University, Taizhou, China.
Wulan LiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jianzhang WuThe Second Affiliated Hospital and Yuying Children's Hospital of the Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structure-activity relationship (SAR) between toxicity and the types of linking ketones of C7 bridged monocarbonyl curcumin analogs (MCAs) was not clear yet. In the pursuit of effective and less cytotoxic chemotherapeutics, we conducted a SAR analysis using various diketene skeletons of C7-bridged MCAs, synthesized cyclic C7-bridged MCAs containing the identified low-toxicity cyclopentanone scaffold and an

Indexed as

Antineoplastic AgentsCurcuminStomach NeoplasmsCell Line, TumorHumansQuantitative Structure-Activity RelationshipStructure-Activity RelationshipAntineoplastic AgentsCurcuminAKT/STAT3 inhibitoranticancer activityCyclic C7 bridged monocarbonyl curcumin analoguesQSAR based on artificial intelligencesynthesis

Identifiers

PMID38385332
PMCPMC10885745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.