Evidence map›Paper›PMID 38385174›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Sex differences in sympathetic activity and pulse wave velocity in adults with chronic kidney disease.

Matias G Zanuzzi, Jinhee Jeong, Dana R DaCosta, Jeanie Park

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Sex-specific modulation of renal epigenetic and injury markers in aging kidney.American journal of physiology. Renal physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matias G ZanuzziDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.ORCID 0000-0002-8598-4998
Jinhee JeongDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.ORCID 0000-0002-8748-8429
Dana R DaCostaDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Jeanie ParkDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.ORCID 0000-0002-5799-9172
Emory University · US

Funding

Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
Neurovascular Regulation During Exercise In Humans With Chronic Kidney DiseaseR01HL135183 · NHLBI · EMORY UNIVERSITY · PI Jeanie Park · 2017 to 2026
$5.4M
Sympatho-inhibition with Mindfulness in Chronic Kidney DiseaseR33AT010457 · NCCIH · EMORY UNIVERSITY · PI PARK, JEANIE · 2022 to 2024
$2.0M
NCATS NIH HHS KL2 TR002381NCCIH NIH HHS R33 AT010457NHLBI NIH HHS R01 HL135183
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is characterized by sympathetic nervous system (SNS) overactivity that contributes to increased vascular stiffness and cardiovascular risk. Although it is well established that SNS activity and vascular stiffness are substantially elevated in CKD, whether sex differences in autonomic and vascular function exist in CKD remains unknown. We tested the hypothesis that compared with females, males with CKD have higher baseline sympathetic activity that is related to increased arterial stiffness. One hundred twenty-nine participants (96 males and 33 females) with CKD stages III and IV were recruited and enrolled. During two separate study visits, vascular stiffness was assessed by measuring carotid-to-femoral pulse wave velocity (cfPWV), and resting muscle sympathetic nerve activity (MSNA) was measured by microneurography. Males with CKD had higher resting MSNA compared with females with CKD (68 ± 16 vs. 55 ± 14 bursts/100 heart beats,

Indexed as

Renal Insufficiency, ChronicVascular StiffnessAdultBlood PressureFemaleHeart RateHumansMalePulse Wave AnalysisSex CharacteristicsSympathetic Nervous Systemautonomicmuscle sympathetic nerve activityrenal diseasevascular stiffnesswomen

Identifiers

PMID38385174
PMCPMC11208017
OpenAlexW4392052255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.