ArticleOsteoarthritis and cartilage open2024
Dual energy computed tomography cannot effectively differentiate between calcium pyrophosphate and basic calcium phosphate diseases in the clinical setting.
Article in Osteoarthritis and cartilage open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Characterization of calcifications in posterior horn of human meniscus using micro-computed tomography.Osteoarthritis and cartilage open · 2026Article
- Characterizing Meniscal Calcifications with Photon Counting-Based Dual-Energy Computed Tomography.Annals of biomedical engineering · 2026Article
- Ultrasonography in the assessment of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Imaging and management of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Chances and challenges of photon-counting CT in musculoskeletal imaging.Skeletal radiology · 2024Review
- Computed tomography-current status and future directions for arthritis imaging.Therapeutic advances in musculoskeletal disease · 2024Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Background: Recent reports suggested that dual-energy CT (DECT) may help discriminate between different types of calcium phosphate crystals Purpose: Our aim was to test the hypothesis that DECT can effectively differentiate basic calcium phosphate (BCP) from calcium pyrophosphate (CPP) deposition diseases. Methods: Discarded tissue after total knee replacement specimens in a 71 year-old patient with knee osteoarthritis and chondrocalcinosis was scanned using DECT at standard clinical parameters. Specimens were then examined on light microscopy which revealed CPP deposition in 4 specimens (medial femoral condyle, lateral tibial plateau and both menisci) without BCP deposition. Regions of interest were placed on post-processed CT images using Rho/Z maps (Syngo.via, Siemens Healthineers, VB10B) in different areas of CPP deposition, trabecular bone BCP (T-BCP) and subchondral bone plate BCP (C-BCP). Results: Dual Energy Index (DEI) of CPP was 0.12 (SD = 0.02) for reader 1 and 0.09 (SD = 0.03) for reader 2, The effective atomic number (Z Conclusion: Differentiation of different types of calcium crystals using DECT is not feasible in a clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.