Evidence map›Paper›PMID 38384852›Full record

ArticleiScience2024

Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis.

Lakshmikanth L Chikkamenahalli, Erik Jessen, Cheryl E Bernard, W K Eddie Ip, Margaret Breen-Lyles, Gianluca Cipriani, Suraj R Pullapantula, Ying Li, Shefaa AlAsfoor, Laura Wilson and 17 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Intestinal muscularis in health and disease.Communications biology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Postoperative delayed gastric emptying: may gut microbiota play a role?Frontiers in cellular and infection microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 12 institutions in 1 country.

Lakshmikanth L ChikkamenahalliDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program, Mayo Clinic, Rochester, MN, USA.
Erik JessenBiomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Cheryl E BernardDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program, Mayo Clinic, Rochester, MN, USA.
W K Eddie IpDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Margaret Breen-LylesDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program, Mayo Clinic, Rochester, MN, USA.
Gianluca CiprianiDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program, Mayo Clinic, Rochester, MN, USA.
Suraj R PullapantulaDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program, Mayo Clinic, Rochester, MN, USA.
Ying LiBiomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Shefaa AlAsfoorDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program, Mayo Clinic, Rochester, MN, USA.
Laura WilsonJohns Hopkins University Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Kenneth L KochWake Forest University, Winston-Salem, NC, USA.
Braden KuoMassachusetts General Hospital, Boston, MA, USA.
Robert J ShulmanBaylor College of Medicine, Houston, TX, USA.
Bruno P ChumpitaziDuke University, Durham, NC, USA.
Travis J McKenzieDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Todd A KelloggDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
James TonasciaJohns Hopkins University Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Frank A HamiltonNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Irene SarosiekTexas Tech University Health Sciences Center, El Paso, TX, USA.
Richard McCallumTexas Tech University Health Sciences Center, El Paso, TX, USA.
Henry P ParkmanTemple University, Philadelphia, PA, USA.
Pankaj J PasrichaMayo Clinic, Scottsdale, AZ, USA.
Thomas L AbellUniversity of Louisville, Louisville, KY, USA.
Gianrico FarrugiaDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program, Mayo Clinic, Rochester, MN, USA.
Surendra DasariBiomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Madhusudan GroverDivision of Gastroenterology and Hepatology, Enteric Neuroscience Program, Mayo Clinic, Rochester, MN, USA.
NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Mayo Clinic in Arizona · USMayo Clinic in Florida · USJohns Hopkins University · USTexas Tech University · USBaylor College of Medicine · USDuke University · USMassachusetts General Hospital · USMayo Clinic · USNational Institute of Diabetes and Digestive and Kidney Diseases · USTemple University · USUniversity of Louisville · USWake Forest University · US

Funding

Gastroparesis Consortium Continuation-Data Coordinating CenterU01DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2006 to 2015
$17.4M
PGpR2 Year 4 Supplement for the Scientific Data Research Center (SDRC) of the GpCRC 4U24DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI David M Shade · 2017 to 2026
$11.7M
Subtypes of GastroparesisU01DK073974 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Baharak Moshiree · 2006 to 2026
$7.4M
Temple University Gastroparesis Clinical CenterU01DK073975 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI HENRY PAUL PARKMAN · 2006 to 2026
$7.4M
U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis ConsortiumU01DK074007 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Thomas Lyman Abell · 2006 to 2026
$7.0M
Molecular Approaches to Pathogenesis/Therapy in GastropaU01DK073983 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PANKAJ J PASRICHA · 2006 to 2026
$6.8M
The GpCRC Pediatric Gastroparesis Registry 2 (PGpR2): Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants with Symptoms of GastU01DK074035 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Irene Sarosiek · 2008 to 2026
$6.7M
Advancing Clinical Science in Pediatric GastroparesisU01DK112194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Bruno Pedro Chumpitazi, Geoffrey A Preidis · 2016 to 2026
$5.3M
New England Gastropareis Consortium: Neurobiology of GastroparesisU01DK112193 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Helen Burton Murray, Braden Kuo · 2016 to 2026
$4.8M
Pathophysiology of Diabetic GastroparesisR01DK127992 · NIDDK · MAYO CLINIC ROCHESTER · PI FARRUGIA, GIANRICO, GROVER, MADHUSUDAN · 2021 to 2024
$2.2M
Microbiota based mechanisms of post-infection irritable bowel syndromeR01DK127998 · NIDDK · MAYO CLINIC ROCHESTER · PI GROVER, MADHUSUDAN · 2021 to 2025
$1.7M
NIDDK NIH HHS R01 DK127992NIDDK NIH HHS R01 DK127998NIDDK NIH HHS U01 DK073974NIDDK NIH HHS U01 DK073975NIDDK NIH HHS U01 DK073983NIDDK NIH HHS U01 DK074007NIDDK NIH HHS U01 DK074008NIDDK NIH HHS U01 DK074035NIDDK NIH HHS U01 DK112193NIDDK NIH HHS U01 DK112194NIDDK NIH HHS U24 DK074008
6 · The paper itself

Abstract

Gastrointestinal immune cells, particularly muscularis macrophages (MM) interact with the enteric nervous system and influence gastrointestinal motility. Here we determine the human gastric muscle immunome and its changes in patients with idiopathic gastroparesis (IG). Single cell sequencing was performed on 26,000 CD45

Indexed as

GastroenterologyImmunologyTranscriptomics

Identifiers

PMID38384852
PMCPMC10879712
OpenAlexW4391116987

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.