Evidence map›Paper›PMID 38384668›Full record

ArticleFrontiers in human neuroscience2023

Tractography-based DBS lead repositioning improves outcome in refractory OCD and depression.

Genevieve Basich-Pease, Natalya Slepneva, Adam C Frank, Tenzin Norbu, Melanie A Morrison, Leo P Sugrue, Paul S Larson, Philip A Starr, A Moses Lee

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2025
    Article
  4. Article
  5. Therapeutic DBS for OCD Suppresses the Default Mode Network.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Genevieve Basich-PeaseWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Natalya SlepnevaWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Adam C FrankWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Tenzin NorbuWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Melanie A MorrisonWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Leo P SugrueWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Paul S LarsonDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
A Moses LeeWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USUniversity of Arizona · US

Funding

Direct Intracranial Electrophysiological Mapping of Insular Circuits for Anxiety in the Human BrainK23MH125018 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, ANDREW MOSES · 2021 to 2025
$1.0M
NIMH NIH HHS K23 MH125018
6 · The paper itself

Abstract

Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) has been used to treat refractory obsessive-compulsive disorder (OCD) and depression, but outcomes are variable, with some patients not responding to this form of invasive neuromodulation. A lack of benefit in some patients may be due to suboptimal positioning of DBS leads. Recently, studies have suggested that specific white matter tracts within the ALIC are associated with improved outcomes. Here, we present the case of a patient who initially had a modest improvement in OCD and depressive symptoms after receiving DBS within the ALIC. Subsequently, he underwent unilateral DBS lead repositioning informed by tractography targeting the ventrolateral and medial prefrontal cortex's connection with the mediodorsal thalamus. In this patient, we also conducted post-implant and post-repositioning diffusion imaging and found that we could successfully perform tractography even with DBS leads in place. Following lead repositioning into tracts predictive of benefit, the patient reached responder criteria for his OCD, and his depression was remitted. This case illustrates that tractography can potentially be used in the evaluation and planning of lead repositioning to achieve therapeutic outcomes.

Indexed as

anterior limb of the internal capsuledeep brain stimulationdiffusion imagingfMRIOCDtractography

Identifiers

PMID38384668
PMCPMC10879278
OpenAlexW4391609726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.