Evidence map›Paper›PMID 38384604›Full record

ArticleCureus2024

A Complete Response to Pembrolizumab in Malignant Peritoneal Mesothelioma: A Case Report.

Maria Bairos Menezes, Rita Pedroso de Lima, Inês Dunões, Mariana Inácio, Rui Dinis

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maria Bairos MenezesMedical Oncology, Hospital Espírito Santo de Évora, Évora, PRT.
Rita Pedroso de LimaSurgery, Hospital Espírito Santo de Évora, Évora, PRT.
Inês DunõesMedical Oncology, Hospital Espírito Santo de Évora, Évora, PRT.
Mariana InácioMedical Oncology, Hospital Espírito Santo de Évora, Évora, PRT.
Rui DinisMedical Oncology, Hospital Espírito Santo de Évora, Évora, PRT.
Hospital do Espírito Santo · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant peritoneal mesothelioma (MPeM) is a rare cancer of the peritoneum with a poor prognosis and nonspecific clinical course. We discuss a case of MPeM in a 59-year-old male who presented with abdominal pain and distension, without any known previous asbestos exposure. The diagnosis was made after a second biopsy finally confirmed epithelioid MPeM in an advanced stage with pleural effusion. The patient underwent six cycles of chemotherapy with cisplatin and pemetrexed, experienced disease progression, and was then started on pembrolizumab as a second-line treatment. The patient achieved a complete response after two years of treatment with pembrolizumab and has been disease-free for almost four years with an Eastern Cooperative Oncology Group (ECOG) performance status of 0. Despite the lack of evidence to support the treatment with immunotherapy for MPeM, our case report encourages its use, highlighting its ability to enable a complete response with pembrolizumab with an excellent quality of life.

Indexed as

clinical complete responseimmune checkpoint inhibitors (icis)immunotherapyinterdisciplinary cancer treatmentmalignant peritoneal mesotheliomapembrolizumabtreatment

Identifiers

PMID38384604
PMCPMC10880429
OpenAlexW4391110888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.