ReviewFrontiers in cellular and infection microbiology2024
Fine-tuning of post-weaning pig microbiome structure and functionality by in-feed zinc oxide and antibiotics use.
Review in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Cross-sectional study characterizing the porcine faecal microbiome in commercial farms.Porcine health management · 2026Article
- From forest to farm: the impact of a broad spectrum of lifestyles on the porcine gut microbiota.Current research in microbial sciences · 2026Article
- The Role of CP Level and Interaction with Antibiotics in the Post-Weaning Piglets' Diet: Growth Performance, Body Composition, Nutrient Digestion, and Intestinal Health.Animals : an open access journal from MDPI · 2025Article
- The impact of early-life rearing conditions on the porcine gut microbiota and immune system.Animal microbiome · 2025Article
- Effects of Tetrabasic Zinc Chloride as Alternative to High Doses of Zinc Oxide on Growth Performance, Nutrient Digestibility, Intestinal Morphology, Immune Function, and Gut Microbiota in Weaned Piglets.Animals : an open access journal from MDPI · 2025Article
- Severity of Brachyspira hyodysenteriae colitis correlates to the changes observed in the microbiota composition and its associated functionality in the large intestine.Animal microbiome · 2025Article
- Performance and intestinal health of piglets in the nursery phase subjected to diets with condensed black wattle (Acacia mearnsii) tannin.Animal bioscience · 2025Article
- Effects of replacing zinc oxide with different levels of zinc lactate on growth performance, serum indexes, intestinal health and gut microbiota in weaned piglets.Frontiers in microbiology · 2025Review
- Modeling the weaning diet of piglets with fermented feed material: effects on growth performance and health parameters.Frontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Post-weaning diarrhoea (PWD) is a multifactorial disease that affects piglets after weaning, contributing to productive and economic losses. Its control includes the use of in-feed prophylactic antibiotics and therapeutic zinc oxide (ZnO), treatments that, since 2022, are no longer permitted in the European Union due to spread of antimicrobial resistance genes and pollution of soil with heavy metals. A dysbiosis in the microbiota has been suggested as a potential risk factor of PWD onset. Understanding pig's microbiota development around weaning and its changes in response to ZnO and antibiotics is crucial to develop feasible alternatives to prophylactic and metaphylactic antimicrobial use. Methods: This study used shotgun metagenomic sequencing to investigate the environmental and faecal microbiota on 10 farms using (Treated) or not using (ZnO-free) in-feed antibiotics and ZnO during the first 14 days post-weaning (dpw). Environmental samples from clean pens were collected at weaning day (0dpw), and faecal samples at 0, 7 and 14dpw. Diarrhoeic faecal samples were collected at 7dpw when available. Results: The analysis of data revealed that the faecal microbiota composition and its functionality was impacted by the sampling time point (microbiota maturation after weaning) but not by the farm environment. Treatment with antibiotics and ZnO showed no effects on diversity indices while the analyses of microbiota taxonomic and functional profiles revealed increased abundance of taxa and metabolic functions associated with Discussion: The results provide a comprehensive overview of the beneficial effects of ZnO and antibiotics in PWD in the microbiota transition after weaning, preventing the overgrowth of pathogens such as pathogenic
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