Evidence map›Paper›PMID 38384179›Full record

Observational studyGut and liver2024

Molecular Activity of Inflammation and Epithelial-Mesenchymal Transition in the Microenvironment of Ulcerative Colitis.

Yu Kyung Jun, Nayoung Kim, Hyuk Yoon, Ji Hyun Park, Hyung Kyung Kim, Yonghoon Choi, Ji Ae Lee, Cheol Min Shin, Young Soo Park, Dong Ho Lee

Registry-linked trialOpen access · diamondAbstract readObservational Study
In one paragraph

Observational study in Gut and liver, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05653011 (Predictors of Response After Induction Therapy With TNF-alpha Inhibitor in Inflammatory Bowel Disease, Comparison to Normal), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05653011 recruitingnot on this map

Predictors of Response After Induction Therapy With TNF-alpha Inhibitor in Inflammatory Bowel Disease, Comparison to Normal

TypeobservationalSponsorSeoul National University Bundang HospitalRan2013 to 2026Enrolled100ConditionsInflammatory Bowel Diseases, Ulcerative Colitis, Crohn DiseaseArmsEndoscopic biopsy
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Stress Granules as Molecular Echoes of Gut Inflammation.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  4. Article
  5. EMT and cancer: what clinicians should know.Nature reviews. Clinical oncology · 2025
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yu Kyung JunDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-4046-8578
Nayoung KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-9397-0406
Hyuk YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-2657-0349
Ji Hyun ParkDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.ORCID 0000-0002-4809-8700
Hyung Kyung KimDepartment of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0003-0271-2493
Yonghoon ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-1331-969X
Ji Ae LeeDepartment of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0003-1493-6208
Cheol Min ShinDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0003-2265-9845
Young Soo ParkDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0003-1893-7726
Dong Ho LeeDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-6376-410X
Seoul National University Bundang Hospital · KRSeoul National University · KRSamsung Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: : The genetic expression in the active inflammatory regions is increased in ulcerative colitis (UC) with endoscopic activity. The aim of this study was to investigate the molecular activity of inflammation and tissue remodeling markers in endoscopically inflamed and uninflamed regions of UC. Methods: : Patients with UC (n=47) and controls (n=20) were prospectively enrolled at the Seoul National University Bundang Hospital. Inflamed tissue was obtained at the most active lesion, and uninflamed tissue was collected from approximately 15 cm above the upper end of the active lesion via colonoscopic biopsies. The messenger RNA expression levels of transforming growth factor β ( Results: : The messenger RNA expressions of Conclusions: : Endoscopic activity in UC suggests inflammation and tissue remodeling of uninflamed regions similar to inflamed regions (ClinicalTrials.gov, NCT05653011).

Indexed as

CadherinsColitis, UlcerativeEpithelial-Mesenchymal TransitionActinsAdultBiomarkersCase-Control StudiesCellular MicroenvironmentColonColonoscopyCytokinesFemaleHumansInflammationInterleukin-1betaIntestinal MucosaActinsBiomarkersCadherinsCytokinesInterleukin-1betaLGR5 protein, humanReceptors, G-Protein-CoupledRNA, MessengerTransforming Growth Factor betaVimentinColitisCytokinesEpithelial-mesenchymal transitionFibrosisulcerative

Identifiers

PMID38384179
PMCPMC11565011
OpenAlexW4392054553

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.