Evidence map›Paper›PMID 38383935›Full record

ArticlePharmaceutical research2024

Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng.

Ying Yu, Li Yun Wang, Yan Chi Liu, Hao Cui, Cheng Yuan, Cheng Xiao Wang

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Role of albumin in regulating platelet function.Frontiers in pharmacology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ying Yu *School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.
Li Yun Wang *School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.
Yan Chi LiuSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.
Hao CuiSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.
Cheng YuanSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. dr.chengyuan@qq.com.
Cheng Xiao WangSchool of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. wcx1192002@126.com.ORCID http://orcid.org/0000-0003-2858-8099
Kunming University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPanax notoginseng saponins (PNS) are commonly used first-line drugs for treating cerebral thrombosis and stroke in China. However, the synchronized and targeted delivery of active ingredients in traditional Chinese medicine (TCM) poses a significant challenge for modern TCM formulations.

methodsBovine serum albumin (BSA) was modified using 2-methacryloyloxyethyl phosphorylcholine (MPC), an analog of acetylcholine, and subsequently adsorbed the major PNS onto the modified albumin to produce MPC-BSA@PNS nanoparticles (NPs). This novel delivery system facilitated efficient and synchronized transport of PNS across the blood-brain barrier (BBB) through active transport mediated by nicotinic acetylcholine receptors.

resultsIn vitro experiments demonstrated that the transport rates of R

conclusionsThis study presents a simple and feasible approach for achieving the targeted delivery of complex active ingredient clusters in TCM.

Indexed as

Panax notoginsengSaponinsAcetylcholineAlbuminsAnimalsBrainAcetylcholineAlbuminsSaponinsblood—brain barrierbrain targetingpanax notoginseng saponins (PNS)synchronous deliverytraditional chinese medicine

Identifiers

PMID38383935
OpenAlexW4391993247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.