Evidence map›Paper›PMID 38383869›Full record

ArticleThe Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology2024

Genetic and clinical study of myeloperoxidase's association with coronary artery disease.

Lina N Adam, Omar A M Al-Habib, Ashur Y Oraha, Mudhir S Shekha

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Lina N AdamDepartment of Biology, College of Science, University of Zakho, Duhok, Kurdistan Region, Iraq. lina.adam@uoz.edu.krd.ORCID http://orcid.org/0000-0001-9977-4388
Omar A M Al-HabibDepartment of Biology, College of Science, University of Nawroz, Duhok, Kurdistan Region, Iraq.ORCID https://orcid.org/0000-0003-0945-4001
Ashur Y OrahaDepartment of Cardiothoracic and Vascular Surgery, College of Medicine, University of Duhok, Duhok, Kurdistan Region, Iraq.ORCID https://orcid.org/0009-0001-2565-1040
Mudhir S ShekhaDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden. mudhir.shekha@mcb.uu.se.ORCID http://orcid.org/0000-0002-9552-838X
Nawroz University · IQUniversity of Duhok · IQUniversity of Zakho · IQUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnraveling myeloperoxidase's (MPO) correlation with coronary artery disease (CAD) and genetic variations, this study seeks to enhance diagnostic precision and therapeutic strategies.

resultsCAD patients were found to be older and more male than controls. Several clinical parameters, including glucose, total bilirubin, alkaline phosphatase, creatinine, and troponin levels, showed significant variations. Moreover, CAD patients had lower red cell distribution width (RDW%) and mean platelet volume (MPV) than controls. Serum MPO levels did not differ significantly between CAD patients and controls, and no correlation was found with other clinical parameters except for glucose, creatinine, and total bilirubin.

conclusionsThe data suggest that serum MPO levels are not substantially related to CAD patients, as indicated by lower MPO levels in CAD patients compared to controls. While highlighting the potential of MPV and RDW% as predictors of severe atherosclerosis in CAD. Further research is needed to validate the diagnostic and prognostic value of RDW%, MPV, and MPO levels in CAD.

trial registration15092021-9-12. Registered 15 September 2021.

Indexed as

BiomarkersCardiovascular riskCoronary artery disease (CAD)Genetic variationMyeloperoxidase (MPO)

Identifiers

PMID38383869
PMCPMC10881921
OpenAlexW4392014776

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.