ArticleCommunications biology2024
On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multivariate brain-behaviour associations in psychiatric disorders.Translational psychiatry · 2024Pooled it
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- Joint-RPCA: domain-aware multi-omics integration for systems microbiology.Molecular systems biology · 2026Article
- Parent-of-origin effects in Alzheimer's liability dissociate neurocognitive and cardiovascular traits in at-risk individuals.Cell reports. Medicine · 2026Article
- Exploration of multidimensional associations between craniomaxillofacial and dental arch structures.BMC oral health · 2026Article
- The topology of adolescent mental health.medRxiv : the preprint server for health sciences · 2026Article
- Loss contexts enhance dorsolateral prefrontal interpersonal neural synchrony during successful human deceptive recommendations.Communications biology · 2026Article
- Replicability of multivariate brain-behaviour associations depends on clinical profile.Communications biology · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- A view-engage-predict framework for enhancing brain-behavior mapping with naturalistic movie-watching fMRI.Communications biology · 2026Article
- Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning.bioRxiv : the preprint server for biology · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- The Hidden Landscape of Missed Effects in Human Functional Neuroimaging.bioRxiv : the preprint server for biology · 2026Article
- A Framework for Advancing Mechanistic Neurobehavioral Biomarkers in Psychiatry.Biological psychiatry · 2026Review
- ENSO-modulated heat source and moisture sink of Asian monsoon and its impact on rice production.Scientific reports · 2026Article
- Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.Scientific reports · 2026Article
- Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study.Molecular psychiatry · 2026Article
- Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts.Nature communications · 2025Article
- Profiles of Aging Based on Cognition, Affect, and Brain Reserve.bioRxiv : the preprint server for biology · 2025Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
Associations between datasets can be discovered through multivariate methods like Canonical Correlation Analysis (CCA) or Partial Least Squares (PLS). A requisite property for interpretability and generalizability of CCA/PLS associations is stability of their feature patterns. However, stability of CCA/PLS in high-dimensional datasets is questionable, as found in empirical characterizations. To study these issues systematically, we developed a generative modeling framework to simulate synthetic datasets. We found that when sample size is relatively small, but comparable to typical studies, CCA/PLS associations are highly unstable and inaccurate; both in their magnitude and importantly in the feature pattern underlying the association. We confirmed these trends across two neuroimaging modalities and in independent datasets with n ≈ 1000 and n = 20,000, and found that only the latter comprised sufficient observations for stable mappings between imaging-derived and behavioral features. We further developed a power calculator to provide sample sizes required for stability and reliability of multivariate analyses. Collectively, we characterize how to limit detrimental effects of overfitting on CCA/PLS stability, and provide recommendations for future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.