Evidence map›Paper›PMID 38383794›Full record

Trial reportEuropean journal of applied physiology2024

Two-week step-reduction has limited negative effects on physical function and metabolic health in older adults.

Simon Walker, Ulla-Maria Sahinaho, Sakari Vekki, Mari Sulonen, Jari A Laukkanen, Sarianna Sipilä, Heikki Peltonen, Eija Laakkonen, Maarit Lehti

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04997447 (Enforced Reduction in Physical Activity and Recovery in Older Adults), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04997447 nacompletednot on this map

Enforced Reduction in Physical Activity and Recovery in Older Adults

TypeinterventionalSponsorUniversity of JyvaskylaRan2021 to 2022Enrolled66ConditionsMuscle Degeneration, Body Weight Changes, Walking, DifficultyArmsStep-reduction/Exercise Rehab
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Simon WalkerFaculty of Sport and Health Sciences, University of Jyväskylä, Room VIV225, 40014-FI, Jyväskylä, Finland. simon.walker@jyu.fi.ORCID http://orcid.org/0000-0002-6804-0741
Ulla-Maria SahinahoFaculty of Sport and Health Sciences, University of Jyväskylä, Room VIV225, 40014-FI, Jyväskylä, Finland.
Sakari VekkiFaculty of Sport and Health Sciences, University of Jyväskylä, Room VIV225, 40014-FI, Jyväskylä, Finland.
Mari SulonenFaculty of Sport and Health Sciences, University of Jyväskylä, Room VIV225, 40014-FI, Jyväskylä, Finland.
Jari A LaukkanenInstitute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3738-1586
Sarianna SipiläFaculty of Sport and Health Sciences, University of Jyväskylä, Room VIV225, 40014-FI, Jyväskylä, Finland.ORCID http://orcid.org/0000-0001-5934-7728
Heikki PeltonenJAMK University of Applied Science, The School of Business, Sport Business, Jyväskylä, Finland.
Eija LaakkonenFaculty of Sport and Health Sciences, University of Jyväskylä, Room VIV225, 40014-FI, Jyväskylä, Finland.ORCID http://orcid.org/0000-0001-6655-9489
Maarit LehtiFaculty of Sport and Health Sciences, University of Jyväskylä, Room VIV225, 40014-FI, Jyväskylä, Finland.ORCID http://orcid.org/0000-0002-9063-6541
University of Jyväskylä · FIJAMK University of Applied Sciences · FIUniversity of Eastern Finland · FI

Funding

Suomen Kulttuurirahasto 00211177
6 · The paper itself

Abstract

purposeThis study determined the effects of a 2-week step-reduction period followed by 4-week exercise rehabilitation on physical function, body composition, and metabolic health in 70-80-year-olds asymptomatic for injury/illness.

methodsA parallel-group randomized controlled trial (ENDURE-study, NCT04997447) was used, where 66 older adults (79% female) were randomized to either intervention or control group. The intervention group reduced daily steps to < 2000, monitored by accelerometer, for two weeks (Period I) and then step-reduction requirement was removed with an additional exercise rehabilitation 4 times per week for 4 weeks (Period II). The control group continued their habitual physical activity throughout with no additional exercise intervention. Laboratory tests were performed at baseline, after Period I and Period II. The primary outcome measure was leg lean mass (LLM). Secondary outcomes included total lean and fat mass, blood glucose and insulin concentration, LDL cholesterol and HDL cholesterol concentration, maximal isometric leg press force (MVC), and chair rise and stair climb performance.

resultsLLM remained unchanged in both groups and no changes occurred in physical function nor body composition in the intervention group in Period I. HDL cholesterol concentration reduced after Period I (from 1.62 ± 0.37 to 1.55 ± 0.36 mmol·L

conclusionShort-term step-reduction in healthy older adults may not be as detrimental to health or physical function as currently thought.

Indexed as

Body CompositionAgedAged, 80 and overBlood GlucoseExerciseExercise TherapyFemaleHumansMaleBlood GlucoseExerciseHDLInactivityPhysical activityStrengthWalking economy

Identifiers

PMID38383794
PMCPMC11199225
OpenAlexW4391993033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.