ArticleNature2024
IL-10 constrains sphingolipid metabolism to limit inflammation.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.
0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
45.4field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
139 citing papers in PubMed, 194 citations in OpenAlex.
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- Zinc sulfate modulates the C3H10T1/2 mesenchymal stem cell line secretome and NFκB signaling during inflammation to influence selected immune cell responses.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
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- Discovery of a potential CERS2 inhibitor: hit compound identification via structure-based virtual screening and molecular dynamics simulations.Molecular diversity · 2026Article
- Microbiome-metabolite signaling networks in gastrointestinal disease: systems biology, network rewiring, and precision therapeutics.Archives of microbiology · 2026Review
- Effects ofAnimals : an open access journal from MDPI · 2026Article
- Dietary anti- Escherichia coli K88 IgY enhances immune response and intestinal barrier function in piglets challenged with Escherichia coli K88.BMC veterinary research · 2026Article
- A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- IL-10 attenuates metabolic dysfunction-associated steatotic liver disease via modulation of hepatic responses to lipotoxicity.JCI insight · 2026Article
- Ceramide-Driven Mechanisms in Pulmonary Fibrosis.Metabolites · 2026Review
- Lacticaseibacillus paracasei 36 attenuates D-GalN/LPS-induced acute liver injury in mice via suppressing the TLR4/NF-κB/MAPK pathway and NLRP3 inflammasome activation through modulating the intestinal microbiota.Journal of advanced research · 2026Article
- Aberrant p53 fuels macrophage immunoregulatory polarization and refractory clinical outcome in urothelial carcinoma.Journal for immunotherapy of cancer · 2026Article
- Review
- The association between plasma IgG N-glycosylation and viral encephalitis in children: a hospital-based case-control study.Italian journal of pediatrics · 2026Article
- Fecal microbiota transplantation mitigates cardiac remodeling and functional impairment in mice with chronic colitis.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Autumn G YorkDepartment of Immunobiology, Yale University, New Haven, CT, USA. AGYork@UW.edu.ORCID 0000-0002-0331-043X
Mathias H SkadowDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Joonseok OhDepartment of Chemistry, Yale University, New Haven, CT, USA.
Rihao QuDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Quan D ZhouDepartment of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-0184-4884
Wei-Yuan HsiehDepartment of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA.
Walter K MowelDepartment of Immunobiology, Yale University, New Haven, CT, USA.
J Richard BrewerDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Eleanna KaffeDepartment of Immunobiology, Yale University, New Haven, CT, USA.
Kevin J WilliamsDepartment of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Yuval KlugerComputational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA.ORCID 0000-0002-3035-071X
Stephen T SmaleHoward Hughes Medical Institute, Yale University, New Haven, CT, USA.
Jason M CrawfordDepartment of Chemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-7583-1242
Steven J BensingerDepartment of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA. SBensinger@mednet.ucla.edu.ORCID 0000-0002-9657-4206
Richard A FlavellDepartment of Immunobiology, Yale University, New Haven, CT, USA. Richard.Flavell@yale.edu.ORCID 0000-0003-4461-0778
Yale University · USUniversity of California, Los Angeles · USHoward Hughes Medical Institute · US
Funding
Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2019 to 2023
$11.7MYale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7MTraining Program in Investigative HepatologyT32DK007356 · NIDDK · YALE UNIVERSITY · PI MICHAEL H NATHANSON · 1986 to 2026
$7.4MHigh Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2MNHLBI NIH HHS P01 HL146358NIDDK NIH HHS T32 DK007356NIDDK NIH HHS U54 DK106857NIH HHS S10 OD030363
Abstract
Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell activation and cytokine production in innate immune cell types
Indexed as
InflammationInterleukin-10SphingolipidsAnimalsCeramidesFatty Acids, UnsaturatedHomeostasisHumansImmunity, InnateMembrane ProteinsMiceProto-Oncogene Proteins c-relSphingosine N-AcyltransferaseTumor Suppressor ProteinsCeramidesCERS2 protein, humanCers2 protein, mouseFatty Acids, UnsaturatedInterleukin-10Membrane ProteinsProto-Oncogene Proteins c-relREL protein, humanSphingolipidsSphingosine N-AcyltransferaseTumor Suppressor Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.