ArticleNature2024
WNT signalling control by KDM5C during development affects cognition.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
14.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Acsl4-mediated Lipid Homeostasis Orchestrates Synaptic and Cognitive Plasticity.Research square · 2026Article
- Genetic analysis and reporting from whole-exome sequencing data in 1052 patients with intellectual disability.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5.Epigenetics & chromatin · 2025Article
- Exploring the Impact of 3-Pharmaceuticals (Basel, Switzerland) · 2025Article
- Evolutionary sex bias in cognitive response to new environmental risk factor - PM2.5.Biology of sex differences · 2025Review
- ZMYND11 Restrains KMT2A to Enable a Neuronal Developmental Program.bioRxiv : the preprint server for biology · 2025Article
- ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis.Nature communications · 2025Article
- Genetic Basis of Non-Syndromic Childhood Glaucoma Associated with Anterior Segment Dysgenesis: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Mutation of CHD7 impairs the output of neuroepithelium transition that is reversed by the inhibition of EZH2.Molecular psychiatry · 2025Article
- Emerging Epigenetic Therapeutics and Diagnostics for Autism Spectrum Disorder.Current issues in molecular biology · 2025Review
- Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets.Journal of translational medicine · 2025Article
- First reported case of de Novo claes-jensen syndrome (CJS) in Palestine: diagnostic challenges and genetic insights.BMC pediatrics · 2025Article
- Review
- A novel KDM5C mutation associated with intellectual disability: molecular mechanisms and clinical implications.Italian journal of pediatrics · 2025Article
- Oligodendrocytes and myelination: pioneering new frontiers in cognitive neuroscience.Frontiers in neuroscience · 2025Review
- Comparing the roles of sex chromosome-encoded protein homologs in gene regulation.Genes & development · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 7 institutions in 7 countries.
Violetta Karwacki-NeisiusDivision of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. violetta.karwacki-neisius@childrens.harvard.edu.ORCID http://orcid.org/0009-0006-6273-9814
Ahram JangDivision of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Engin Cukuroglu *Computational and Systems Biology, Genome Institute of Singapore, Singapore, Singapore.
Albert Tai *Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7771-0850
Alan Jiao *Division of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Danilo Predes *Department of Neurology, F. M Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1864-0324
Joon Yoon *Department of Biostatistics, The Harvard Chan School of Public Health, Bioinformatics Core, Cambridge, MA, USA.
Emily Brookes *Division of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2175-4349
Jiekai ChenDivision of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5168-7074
Aimee IbergDivision of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Florian HalbritterChildren's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.ORCID http://orcid.org/0000-0003-2452-4784
Katrin ÕunapDepartment of Clinical Genetics, Genetic and Personalized Medicine Clinic, Tartu University Hospital, Tartu, Estonia.ORCID http://orcid.org/0000-0002-4594-6364
Jozef GeczAdelaide Medical School and Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-7884-6861
Thorsten M SchlaegerStem Cell Program, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1599-9908
Shannan Ho SuiDepartment of Biostatistics, The Harvard Chan School of Public Health, Bioinformatics Core, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6191-4709
Jonathan GökeComputational and Systems Biology, Genome Institute of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-0825-4991
Xi HeDepartment of Neurology, F. M Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8093-7981
Maria K LehtinenDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7243-2967
Scott L PomeroyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yang ShiDivision of Newborn Medicine and Epigenetics Program, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. yang.shi@ludwig.ox.ac.uk.ORCID http://orcid.org/0000-0001-9713-1709
Boston Children's Hospital · USGenome Institute of Singapore · SGBroad Institute · USSt Anna Children's Hospital · ATTartu University Hospital · EEThe University of Adelaide · AUTufts University · US
Funding
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MNovel epigenetic mechanisms in neuronal development and cognitive functionR01MH096066 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI ARLOTTA, PAOLA, POMEROY, SCOTT LOREN · 2012 to 2022
$6.1MControl of neural stem cells by the nascent cerebrospinal fluidR01NS088566 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI LEHTINEN, MARIA · 2014 to 2024
$5.5MWnt Signaling and Vertebrate embryogenesisR35GM134953 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI HE, XI · 2020 to 2024
$3.8MNCATS NIH HHS UL1 TR002541NICHD NIH HHS P50 HD105351NIGMS NIH HHS R35 GM134953NIMH NIH HHS R01 MH096066NINDS NIH HHS R01 NS088566
Abstract
Although KDM5C is one of the most frequently mutated genes in X-linked intellectual disability
Indexed as
CognitionEmbryo, MammalianEmbryonic DevelopmentHistone DemethylasesWnt Signaling PathwayAnimalsAnxietyChromatinGene Expression ProfilingHumansInduced Pluripotent Stem CellsIntellectual DisabilityMemoryMiceMice, KnockoutMutationChromatinHistone DemethylasesKDM5C protein, humanKdm5c protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.