ArticleNature2024
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 59 citations in OpenAlex.
- Central T cell tolerance from sparse peptide sampling.Science advances · 2026Article
- Narcolepsy is (not) an autoimmune disease.Nature reviews. Neurology · 2026Review
- Focal astrocyte loss reveals nuclear translocation during lesion repopulation.Nature neuroscience · 2026Article
- Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders.Nature communications · 2026Article
- Curing the brain: in search for new astrocyte-specific therapies.Experimental & molecular medicine · 2026Review
- Natalizumab exacerbates astrocytopathy in NMOSD via blockade of endothelial VCAM1-astrocytic integrin α4 interaction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Multi-omics profiling reveals intrathymic triggers and novel biomarkers in thymoma-associated myasthenia gravis.Biomarker research · 2026Article
- Patient-Derived Monoclonal Myelin Oligodendrocyte Glycoprotein Autoantibodies Mediate Cytotoxicity.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Sjögren Syndrome Candidate Autoantigen AQP5 Triggers AQP4 CNS Autoimmunity Through Self-Antigen Mimicry.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Gut microbiota-neuroimmune crosstalk in autoimmune encephalitis: mechanistic insights and therapeutic prospects.Frontiers in microbiology · 2026Review
- Dissecting NMOSD pathogenesis through animal models: a mechanism-oriented systems perspective.Frontiers in immunology · 2026Review
- AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective.Frontiers in immunology · 2026Review
- Fezf2 regulates differentiation of Aire-expressing and post-Aire mimetic epithelial populations maintaining thymic homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Predict disabling severe attacks in neuromyelitis optica spectrum disorders: warning symptoms and innovative machine learning models.Journal of translational medicine · 2025Article
- Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Paradigms, innovations, and biological applications of RNA velocity: a comprehensive review.Briefings in bioinformatics · 2025Review
- Thymic central tolerance takes centre stage in autoimmune disease.The Lancet regional health. Western Pacific · 2025Article
- Thymic Interferons: A Little Goes a Long Way.Immunological reviews · 2025Review
- Thymflammation: The Role of a Constitutively Active Inflammatory Network and "Ectopic" Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond.Immunological reviews · 2025Review
- Self-Antigens Select B Cells: A New Perspective on B Cell Selection and Function.European journal of immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 9 institutions in 3 countries.
Ali Maisam AfzaliInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-3256-5298
Lucy NirschlInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.
Christopher SieInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-8066-7539
Monika PfallerInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.
Oleksii UlianovInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0009-0005-4944-9815
Tobias HasslerBiomedical Center (BMC), Institute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Christine FederleBiomedical Center (BMC), Institute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Elisabetta PetrozzielloBiomedical Center (BMC), Institute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Sudhakar Reddy KalluriDepartment of Neurology, Technical University of Munich School of Medicine and Health, Munich, Germany.
Hsin Hsiang ChenInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0003-2496-0607
Sofia TyystjärviInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-5057-1923
Andreas MuschaweckhInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-6870-1378
Katja LammensDepartment of Biochemistry at the Gene Center, Ludwig-Maximilians-University, Munich, Germany.ORCID 0000-0002-4438-1381
Claire DelbridgeInstitute of Pathology, Technical University of Munich School of Medicine and Health, Munich, Germany.
Andreas BüttnerInstitute of Forensic Medicine, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0002-6676-4957
Katja SteigerInstitute of Pathology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-7269-5433
Gönül SeyhanInstitute for Experimental Hematology, TranslaTUM Cancer Center, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-3879-8009
Ole Petter OttersenDivision of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.ORCID 0000-0003-1048-219X
Rupert ÖllingerInstitute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-2292-5982
Roland RadInstitute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-6849-9659
Sebastian JaroschInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-2908-8590
Adrian StraubInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0003-4200-5785
Anton MühlbauerInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich School of Medicine and Health, Munich, Germany.
Simon GrassmannImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-8336-3418
Bernhard HemmerDepartment of Neurology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0001-5985-6784
Jan P BöttcherInstitute of Molecular Immunology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-8163-8107
Ingrid WagnerDepartment of Pathology and Immunology, Division of Clinical Pathology, Geneva Faculty of Medicine, Centre Médical Universitaire, Geneva, Switzerland.ORCID 0000-0003-4437-9799
Mario KreutzfeldtDepartment of Pathology and Immunology, Division of Clinical Pathology, Geneva Faculty of Medicine, Centre Médical Universitaire, Geneva, Switzerland.
Doron MerklerDepartment of Pathology and Immunology, Division of Clinical Pathology, Geneva Faculty of Medicine, Centre Médical Universitaire, Geneva, Switzerland.ORCID 0000-0002-0247-2007
Irene Bonafonte PardàsInstitute for Computational Biology, Helmholtz Munich, Neuherberg, Germany.
Marc Schmidt SupprianInstitute for Experimental Hematology, TranslaTUM Cancer Center, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-8543-6166
Veit R BuchholzInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0003-0441-3913
Sylvia HeinkInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0002-3276-6313
Dirk H BuschInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich School of Medicine and Health, Munich, Germany.ORCID 0000-0001-8713-093X
Ludger KleinBiomedical Center (BMC), Institute for Immunology, Faculty of Medicine, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.ORCID 0000-0003-2054-071X
Thomas KornInstitute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Munich, Germany. thomas.korn@tum.de.ORCID 0000-0002-3633-0955
Technical University of Munich · DELudwig-Maximilians-Universität München · DEInstitute of Medical Microbiology and Hygiene · DEMunich Cluster for Systems Neurology · DEGerman Center for Infection Research · DEHelmholtz Zentrum München · DEMemorial Sloan Kettering Cancer Center · USUniversity of Oslo · NOUniversity of Rostock · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MNCI NIH HHS P30 CA008748
Abstract
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen
Indexed as
Aquaporin 4AutoantibodiesAutoantigensB-LymphocytesImmune ToleranceNeuromyelitis OpticaAIRE ProteinAnimalsCD40 AntigensGerminal CenterHumansInterleukin-21MiceReceptors, Antigen, T-CellThymus GlandThyroid Epithelial CellsAIRE ProteinAQP4 protein, humanAqp4 protein, mouseAquaporin 4AutoantibodiesAutoantigensCD40 AntigensInterleukin-21Receptors, Antigen, T-Cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.