Evidence map›Paper›PMID 38383709›Full record

ArticleScientific reports2024

Insulin and IGF-1 have both overlapping and distinct effects on CD4

Kaitlin Kiernan, Yazan Alwarawrah, Amanda G Nichols, Keiko Danzaki, Nancie J MacIver

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kaitlin KiernanDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
Yazan AlwarawrahDepartment of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Amanda G NicholsDepartment of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Keiko DanzakiDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
Nancie J MacIverDepartment of Pediatrics, Division of Pediatric Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. nancie_maciver@med.unc.edu.
University of North Carolina at Chapel Hill · USDuke University · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
Leptin as a Regulator of T Cell Metabolism and FunctionK08DK087944 · NIDDK · DUKE UNIVERSITY · PI MACIVER, NANCIE · 2010 to 2014
$678k
Metabolic reprogramming to improve EGFRvIII CAR T cell persistenceR21CA253163 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MACIVER, NANCIE · 2021 to 2022
$402k
NCI NIH HHS K12 CA090625NCI NIH HHS R21 CA253163NIAID NIH HHS T32 AI052077NIDDK NIH HHS K08 DK087944NIDDK NIH HHS P30 DK056350NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Insulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on CD4

Indexed as

InsulinInsulin-Like Growth Factor ICD4-Positive T-LymphocytesMitochondriaReceptor, IGF Type 1Receptor, InsulinSignal TransductionInsulinInsulin-Like Growth Factor IReceptor, IGF Type 1Receptor, Insulin

Identifiers

PMID38383709
PMCPMC10881490
OpenAlexW4391991820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.