Evidence map›Paper›PMID 38383591›Full record

ArticleActa neuropathologica communications2024

The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis.

Bert M Verheijen, Claire Chung, Ben Thompson, Hyunjin Kim, Asa Nakahara, Jasper J Anink, James D Mills, NYGC ALS Consortium, Jeong H Lee, Eleonora Aronica and 4 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Improvement ofFrontiers in pharmacology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Novel Techniques for Mapping DNA Damage and Repair in the Brain.International journal of molecular sciences · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bert M VerheijenSchool of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. l.m.verheijen1@gmail.com.
Claire ChungSchool of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Ben ThompsonGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Hyunjin KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Asa NakaharaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Jasper J AninkDepartment of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
James D MillsDepartment of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
NYGC ALS Consortium
Jeong H LeeGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Eleonora AronicaDepartment of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Kiyomitsu OyanagiDivision of Neuropathology, Department of Brain Disease Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Jean-Francois GoutDepartment of Biological Sciences, Mississippi State University, Mississippi State, MS, 39762, USA.
Marc VermulstSchool of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.

Funding

DNA-damage-induced transcription errors provide a constant stream of amyloid and prion-like proteins in human cellsR01AG083065 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Marc Vermulst · 2024 to 2026
$2.1M
Understanding the role of transcription errors in aging and diseaseR01AG054641 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VERMULST, MARC · 2017 to 2021
$1.7M
NIA NIH HHS R01 AG054641NIA NIH HHS R01AG054641NIA NIH HHS R01 AG083065
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisMutagensGuamHumansMethylazoxymethanol AcetateMutagenesismethylazoxymethanolMethylazoxymethanol AcetateMutagensDNA damageEnvironmental toxinGuam amyotrophic lateral sclerosis/parkinsonism–dementia complexO6-mGTranscriptional mutagenesis

Identifiers

PMID38383591
PMCPMC10882831

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.