ArticleScientific reports2024
Directed functional connectivity of the default-mode-network of young and older healthy subjects.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Predicting trail-making test performance using 7-Tesla structural cerebral MRI.Translational psychiatry · 2026Article
- Functional brain network alterations linked to cancer-related cognitive impairment in breast cancer patients.The oncologist · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Replicability of Functional Brain Networks: A Study Through the Lens of Seven Resting-State Networks.Human brain mapping · 2026Article
- Sub-Regional Motor-Somatosensory Connectivity and Lifespan Plasticity in Functional Networks.Neurosciences (Riyadh, Saudi Arabia) · 2026Article
- Consciousness, subjectivity, and aging in western thought.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Velocities of hippocampal traveling waves are proportional to their coherence frequency.PloS one · 2025Article
- Age-related alterations in functional and structural networks in the brain in macaque monkeys.Frontiers in neuroanatomy · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a novel multivariate analysis method on resting-state functional MRI data from fifty young and thirty-one healthy older subjects, we calculated intra- and inter-DMN 4-nodes directed pathways. For the old subject group, we calculated the partial correlations of inter-DMN pathways with: psychomotor speed and working memory, executive function, language, long-term memory and visuospatial function. Pathways connecting the DMN with visual and limbic regions in older subjects engaged at BOLD low frequency and involved the dorsal posterior cingulate cortex (PCC), whereas in young subjects, they were at high frequency and involved the ventral PCC. Pathways combining the sensorimotor (SM) cortex and the DMN, were SM efferent in the young subjects and SM afferent in the older subjects. Most DMN efferent pathways correlated with reduced speed and working memory. We suggest that the reduced sensorimotor efferent and the increased need to control such activities, cause a higher dependency on external versus internal cues thus suggesting how physical activity might slow aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.