ArticleNPJ Parkinson's disease2024
Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS.
Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Mechanism and progress of deep brain stimulation in the treatment of neurological and psychiatric disorders.MedScience · 2026Review
- From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.Surgical neurology international · 2026Review
- Distance of bipolar re-referencing imparts nonlinear frequency-specific influences on intracranial recording signal measurements.Journal of neural engineering · 2025Article
- Structural Connectivity of the Basal Ganglia from Patient-Individual Tractography Is Key for Understanding the Effects of Deep Brain Stimulation in Parkinson's Disease.Stereotactic and functional neurosurgery · 2025Article
- Revealing connectivity patterns of deep brain stimulation efficacy in Parkinson's disease.Scientific reports · 2024Article
- Beta-band power classification of go/no-go arm-reaching responses in the human hippocampus.Journal of neural engineering · 2024Article
- Current and future applications of local field potential-guided programming for Parkinson's disease with the Percept™ rechargeable neurostimulator.Neurodegenerative disease management · 2024Review
- Deep brain stimulation for Parkinson's disease: bibliometric analysis of the top 100 cited literature.Frontiers in aging neuroscience · 2024Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Beta hypersynchrony was recently introduced into clinical practice in Parkinson's disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication "off" state. Coupling between beta power and HFOs is known to be a correlate of the PD "off" state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.