ArticleNature communications2024
Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
43.2field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Pooled it
- Acupressure and Qigong in post-infectious fatigue with impaired physical function: a randomized clinical trial.Frontiers in medicine · 2026Trial
- Brief Outpatient Rehabilitation Program for Post-COVID-19 Condition: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Safety, Immunovirologic, and Central Nervous System Effects of PD-1 Inhibition in People With HIV Without Malignancy.The Journal of infectious diseases · 2026Article
- Characterization and validation of EHR computable phenotypes for Long COVID using patient-reported symptoms: insights from the nationwide RECOVER program.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Epigenome-wide profiling identifies distinct DNA methylation architecture underlying ME/CFS and fibromyalgia symptom burden.Journal of translational medicine · 2026Article
- Neurological Manifestations in Adult Survivors of Ebola Virus Disease.JAMA neurology · 2026Article
- Circulating extracellular vesicles-microRNAs as potential biomarkers for the identification of ME/CFS: differentiating fatigue-related conditions.Journal of translational medicine · 2026Article
- Autonomic Dysfunction in Patients withPathogens (Basel, Switzerland) · 2026Article
- Gastrointestinal symptoms correlate with core clinical features and systemic inflammation in myalgic encephalomyelitis/chronic fatigue syndrome.Journal of translational medicine · 2026Article
- Fatigue-associated gut bacteria in Japanese healthy adults characterized by metagenomic analysis.Scientific reports · 2026Article
- Designing studies for post-treatment Lyme disease and other infection-associated chronic illnesses.Brain : a journal of neurology · 2026Review
- Tryptophan Metabolism and Aryl-Hydrocarbon Receptor Agonists in the Gut Microbiome of People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.MicrobiologyOpen · 2026Article
- Reframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases.Journal of translational medicine · 2026Review
- Chronic fatigue syndrome in nursing practice: a concept analysis.BMC nursing · 2026Article
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome diagnostic reporting in the 2021-2023 National Health Interview Survey.BMC public health · 2026Article
- Imbalance of Excitatory and Inhibitory Neurotransmitter Systems in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.International journal of molecular sciences · 2026Review
- Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID.Communications medicine · 2026Article
- Symptom clusters in ME/CFS reflect distinct neuroimmune and autonomic pathophysiological mechanisms: a translational model.Journal of translational medicine · 2026Article
- Long COVID: Deep single-cell immunophenotyping and machine learning reveal a general signature for fatigue.Journal of translational medicine · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
71 authors at 20 institutions in 3 countries.
Brian WalittNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Komudi SinghNational Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA.ORCID 0000-0002-6413-541X
Samuel R LaMunionNational Institute of Diabetes, Digestion, and Kidney Disease (NIDDK), Bethesda, MD, USA.ORCID 0000-0002-7290-5189
Mark HallettNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0002-3180-6811
Steve JacobsonNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Kong ChenNational Institute of Diabetes, Digestion, and Kidney Disease (NIDDK), Bethesda, MD, USA.ORCID 0000-0002-0306-1904
Yoshimi Enose-AkahataNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0002-7102-9703
Richard AppsNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA.
Jennifer J BarbNIH Clinical Center (CC), Bethesda, MD, USA.ORCID 0000-0003-3022-0154
Patrick BedardNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0001-9447-6779
Robert J BrychtaNational Institute of Diabetes, Digestion, and Kidney Disease (NIDDK), Bethesda, MD, USA.ORCID 0000-0001-9491-7968
Ashura Williams BuckleyNational Institute of Mental Health (NIMH), Bethesda, MD, USA.
Peter D BurbeloNational Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA.ORCID 0000-0003-1717-048X
Brice CalcoNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Brianna CathayTexas A&M School of Engineering Medicine, College Station, TX, USA.
Li ChenAffiliated Hospital of North Sichuan Medical College, Sichuan, China.
Snigdha ChigurupatiGeorge Washington University Hospital, District of Columbia, Washington, DC, USA.
Jinguo ChenNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA.
Foo CheungNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA.
Lisa M K ChinNIH Clinical Center (CC), Bethesda, MD, USA.
Benjamin W ColemanAllegheny General Hospital, Pittsburgh, PA, USA.
Amber B CourvilleNational Institute of Diabetes, Digestion, and Kidney Disease (NIDDK), Bethesda, MD, USA.ORCID 0000-0002-1419-3937
Madeleine S DemingNIH Clinical Center (CC), Bethesda, MD, USA.
Bart DrinkardNIH Clinical Center (CC), Bethesda, MD, USA.
Li Rebekah FengNational Institute on Drug Abuse (NIDA), Bethesda, MD, USA.ORCID 0000-0003-0445-4088
Luigi FerrucciNational Institute of Aging (NIA), Baltimore, MD, USA.ORCID 0000-0002-6273-1613
Scott A GabelNational Institute of Environmental Health Sciences (NIEHS), Chapel Hill, NC, USA.
Angelique GavinNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
David S GoldsteinNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0002-5709-9940
Shahin HassanzadehNational Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA.
Sean C HoranSidney Kimmel Medical College, Philadelphia, PA, USA.ORCID 0009-0005-2375-4133
Silvina G HorovitzNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Kory R JohnsonNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0002-6693-3378
Anita Jones GovanNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Kristine M KnutsonNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0003-4626-4514
Joy D KreskowNational Institute of Nursing Research (NINR), Bethesda, MD, USA.
Mark LevinNational Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA.ORCID 0000-0002-2241-9828
Jonathan J LyonsNational Institute of Allergy and Infectious Disease (NIAID), Bethesda, MD, USA.ORCID 0000-0002-2346-8189
Nicholas MadianNational Center for Complementary and Integrative Health (NCCIH), Bethesda, MD, USA.ORCID 0000-0001-5325-546X
Nasir MalikNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Andrew L MammenNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.ORCID 0000-0003-3732-3252
John A McCullochNational Cancer Institute (NCI), Bethesda, MD, USA.ORCID 0000-0001-7107-6561
Patrick M McGurrinNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0002-6962-9582
Joshua D MilnerColumbia University Medical Center, New York, NY, USA.ORCID 0000-0002-3913-3869
Ruin MoaddelNational Institute of Aging (NIA), Baltimore, MD, USA.
Geoffrey A MuellerNational Institute of Environmental Health Sciences (NIEHS), Chapel Hill, NC, USA.ORCID 0000-0001-8361-5323
Amrita MukherjeeNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA.
Sandra Muñoz-BracerasNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.
Gina NoratoNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Katherine PakNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.
Iago Pinal-FernandezNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA.ORCID 0000-0001-6338-9218
Traian PopaNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0003-1160-4830
Lauren B ReomaNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Michael N SackNational Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA.
Farinaz SafaviNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Leorey N SaliganNational Institute of Nursing Research (NINR), Bethesda, MD, USA.ORCID 0000-0001-9481-7836
Brian A SellersNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA.
Stephen SinclairNational Institute of Mental Health (NIMH), Bethesda, MD, USA.
Bryan SmithNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Joseph SnowNational Institute of Mental Health (NIMH), Bethesda, MD, USA.
Stacey SolinNIH Clinical Center (CC), Bethesda, MD, USA.
Barbara J StussmanNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.
Giorgio TrinchieriNational Cancer Institute (NCI), Bethesda, MD, USA.
Sara A TurnerNIH Clinical Center (CC), Bethesda, MD, USA.
C Stephenie VetterUniversity of Colorado School of Medicine, Boulder, CO, USA.ORCID 0000-0002-4694-677X
Felipe VialClínica Alemana Universidad del Desarrollo, Santiago, Chile.
Carlotta VizioliNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.ORCID 0000-0002-5066-7386
Ashley WilliamsOakland University William Beaumont School of Medicine, Rochester, NY, USA.
Shanna B YangNIH Clinical Center (CC), Bethesda, MD, USA.
Center for Human Immunology, Autoimmunity, and Inflammation (CHI) Consortium
Avindra NathNational Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA. Avindra.nath@nih.gov.ORCID 0000-0003-0927-5855
National Institute of Neurological Disorders and Stroke · USNational Institutes of Health Clinical Center · USNational Heart Lung and Blood Institute · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institute of Mental Health · USNational Cancer Institute · USNational Center for Complementary and Integrative Health · USNational Institute of Environmental Health Sciences · USNational Institute of Nursing Research · USNational Institute on Aging · USAffiliated Hospital of North Sichuan Medical College · CNAllegheny General Hospital · USColumbia University Irving Medical Center · USGeorge Washington University Hospital · USNational Institute of Allergy and Infectious Diseases · USNational Institute of Dental and Craniofacial Research · USNational Institute on Drug Abuse · USOakland University · USSidney Kimmel Cancer Center · US
Funding
Center for Human Immunology ZICAI001226 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2018 to 2025
$34.1MLICI Microbiome and Genetics CoreZICBC011237 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OHUIGIN, COLM · 2009 to 2025
$28.3MBiomarkers of Parkinson Disease and Related DisordersZIANS003034 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2009 to 2025
$22.8MRole of mouse microbiome in cancer and inflammationZIABC011153 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$22.0MMuscle Disease UnitZIAAR041203 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI MAMMEN, ANDREW · 2015 to 2025
$19.7MMitochondrial biology in diabetesZIAHL005199 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2009 to 2025
$17.2MPost-Viral SyndromesZIANS003157 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2016 to 2025
$13.5MInvestigating Molecular-Genetic Correlates of FatigueZIANR000019 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI SALIGAN, LEOREY · 2010 to 2025
$12.8MMetabolic Research Core: energy balance and obesity studiesZICDK071013 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CHEN, KONG · 2009 to 2025
$12.3MDevelopment of obesity and metabolic clinical research programsZIADK071014 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CHEN, KONG · 2009 to 2025
$12.3MPsychiatry Consultation Liaison Service ResearchZIAMH002922 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PAO, MARYLAND · 2009 to 2025
$11.5MWilliams syndrome: A Translational Approach to Mechanism and TreatmentZIAHL006210 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KOZEL, BETH · 2016 to 2024
$10.4MIntramural NIH HHS Z01 HL005199Intramural NIH HHS ZIA DK071014Intramural NIH HHS ZIA HL005199Intramural NIH HHS ZIA HL006210Intramural NIH HHS ZIA HL006212Intramural NIH HHS ZIA MH002922Intramural NIH HHS ZIA NS003157Intramural NIH HHS ZIC ES103362NIAID NIH HHS SI2 AI138586NIDDK NIH HHS R01 DK071014U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL006210; HL006212; HL005199U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) ES103362U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH002922U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS3157
Abstract
Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning. Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention.
Indexed as
Communicable DiseasesFatigue Syndrome, ChronicBiomarkersHumansLeukocytes, MononuclearPhenotypeBiomarkers
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