Evidence map›Paper›PMID 38383440›Full record

ArticleBioPsychoSocial medicine2024

Atypical social cognition processing in bulimia nervosa: an fMRI study of patients thinking of others' mental states.

Rio Kamashita, Rikukage Setsu, Noriko Numata, Yasuko Koga, Michiko Nakazato, Koji Matsumoto, Hiroki Ando, Yoshitada Masuda, Sertap Maral, Eiji Shimizu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioPsychoSocial medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rio KamashitaResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Rikukage SetsuDepartment of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Noriko NumataResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Yasuko KogaResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Michiko NakazatoDepartment of Clinical Psychiatry, Chiba University Hospital, Chiba, Japan.
Koji MatsumotoDepartment of Radiology, Chiba University Hospital, Chiba, Japan.
Hiroki AndoDepartment of Radiology, Chiba University Hospital, Chiba, Japan.
Yoshitada MasudaDepartment of Radiology, Chiba University Hospital, Chiba, Japan.
Sertap MaralUnited Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan.
Eiji ShimizuResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Yoshiyuki HiranoResearch Center for Child Mental Development, Chiba University, Chiba, Japan. hirano@chiba-u.jp.ORCID http://orcid.org/0000-0003-3844-3061

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFeeding and eating disorders are severe mental disorders that gravely affect patients' lives. In particular, patients with anorexia nervosa (AN) or bulimia nervosa (BN) appear to have poor social cognition. Many studies have shown the relationship between poor social cognition and brain responses in AN. However, few studies have examined the relationship between social cognition and BN. Therefore, we examined which brain regions impact the ability for social cognition in patients with BN.

methodsWe used task-based functional magnetic resonance imaging (fMRI) to examine brain responses during a social cognition task and the Reading Mind in the Eyes Test (RMET). During the fMRI, 22 women with BN and 22 healthy women (HW) took the RMET. Participants also completed the eating disorder clinical measures Bulimic Investigatory Test, Edinburgh (BITE) and Eating Disorders Examination Questionnaire (EDE-Q), the Patient Health Questionnaire (PHQ-9) measure of depression; and the Generalized Anxiety Disorder (GAD-7) measure of anxiety.

resultsNo difference was observed in the RMET scores between women with BN and HW. Both groups showed activation in brain regions specific to social cognition. During the task, no differences were shown between the groups in the BOLD signal (p < 0.05, familywise error corrected for multiple comparisons). However, there was a tendency of more robust activation in the right angular gyrus, ventral diencephalon, thalamus proper, temporal pole, and middle temporal gyrus in BN (p < 0.001, uncorrected for multiple comparisons). Moreover, HW showed a positive correlation between RMET scores and the activation of two regions: medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC); however, no significant correlation was observed in women with BN.

conclusionsWhile activation in the mPFC and ACC positively correlated to the RMET scores in HW, no correlation was observed in BN patients. Therefore, women with BN might display modulated neural processing when thinking of others' mental states. Further examination is needed to investigate neural processing in BN patients to better understand their social cognition abilities.

trial registrationUMIN, UMIN000010220. Registered 13 March 2013, https://rctportal.niph.go.jp/s/detail/um?trial_id=UMIN000010220.

Indexed as

Bulimia nervosaEating disordersSocial cognitionTask-based fMRITheory of mind

Identifiers

PMID38383440
PMCPMC10880368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.