SynthesisInternational journal for equity in health2024
Rapid systematic review on risks and outcomes of sepsis: the influence of risk factors associated with health inequalities.
Synthesis in International journal for equity in health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Cost-Effectiveness of a Host-Response Point-of-Care Assay for Early Sepsis Diagnosis in UK Emergency Departments.Molecular diagnosis & therapy · 2026Article
- Factors Associated With Elevated Sepsis in Obstetrics Scores Among Antenatal Women: An Analytical Study.Cureus · 2026Article
- ASP-COMPLEX: redefining antimicrobial stewardship to improve outcomes in high-risk patients with severe infections.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Age-Comorbidity Interactions and Clinical Outcomes in Septic Shock: An Emergency Department-Based Multicenter Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- The association between different aspects of socioeconomic deprivation and severe maternal morbidity.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Temporal trends in sepsis hospitalisations and mortality in Aotearoa New Zealand, 2000-2019: a population-based study.The Lancet regional health. Western Pacific · 2025Article
- An interpretable machine learning approach to prognosis of melioidosis pneumonia via computed tomography quantification and clinical data.Scientific reports · 2025Article
- Sex-related differences in antimicrobial dosing for sepsis: Bridging the equity gap.Journal of intensive medicine · 2025Article
- Beyond the Incision: Pediatric Postoperative Sepsis Risk Patterns and Related Adverse Events in U.S. Inpatient Care.Healthcare (Basel, Switzerland) · 2025Article
- Examining socioeconomic differences in sepsis risk and mediation by modifiable factors: a Mendelian randomization study.BMC infectious diseases · 2025Article
- Correlation Between Platelet Indices and Severity of Sepsis: A Hospital-Based Prospective Study.Cureus · 2025Article
- Article
- Nursing Student Knowledge Related to Sepsis in Croatian, Cypriot, and Greek Universities: A Cross-Sectional European Study.International journal of environmental research and public health · 2024Article
- Drp1-associated genes implicated in sepsis survival.Frontiers in immunology · 2024Article
- Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis.Frontiers in genetics · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsSepsis is a serious and life-threatening condition caused by a dysregulated immune response to an infection. Recent guidance issued in the UK gave recommendations around recognition and antibiotic treatment of sepsis, but did not consider factors relating to health inequalities. The aim of this study was to summarise the literature investigating associations between health inequalities and sepsis.
methodsSearches were conducted in Embase for peer-reviewed articles published since 2010 that included sepsis in combination with one of the following five areas: socioeconomic status, race/ethnicity, community factors, medical needs and pregnancy/maternity.
resultsFive searches identified 1,402 studies, with 50 unique studies included in the review after screening (13 sociodemographic, 14 race/ethnicity, 3 community, 3 care/medical needs and 20 pregnancy/maternity; 3 papers examined multiple health inequalities). Most of the studies were conducted in the USA (31/50), with only four studies using UK data (all pregnancy related). Socioeconomic factors associated with increased sepsis incidence included lower socioeconomic status, unemployment and lower education level, although findings were not consistent across studies. For ethnicity, mixed results were reported. Living in a medically underserved area or being resident in a nursing home increased risk of sepsis. Mortality rates after sepsis were found to be higher in people living in rural areas or in those discharged to skilled nursing facilities while associations with ethnicity were mixed. Complications during delivery, caesarean-section delivery, increased deprivation and black and other ethnic minority race were associated with post-partum sepsis.
conclusionThere are clear correlations between sepsis morbidity and mortality and the presence of factors associated with health inequalities. To inform local guidance and drive public health measures, there is a need for studies conducted across more diverse setting and countries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.