Evidence map›Paper›PMID 38383295›Full record

ArticleBMC genomics2024

Transcriptomic basis of sex loss in the pea aphid.

M D Huguet, S Robin, S Hudaverdian, S Tanguy, N Leterme-Prunier, R Cloteau, S Baulande, P Legoix-Né, F Legeai, J-C Simon and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

M D HuguetInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
S RobinInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
S HudaverdianInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
S TanguyInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
N Leterme-PrunierInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
R CloteauInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
S BaulandeCentre de Recherche, Genomics of Excellence Platform, Institut Curie, PSL Research University, Paris Cedex 05, France.
P Legoix-NéCentre de Recherche, Genomics of Excellence Platform, Institut Curie, PSL Research University, Paris Cedex 05, France.
F LegeaiInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
J-C SimonInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
J JaquiéryInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
D TaguInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France.
G Le TrionnaireInstitute for Genetics, Environment and Plant Protection, IGEPP, INRAE, Institut Agro, Univ Rennes, Le Rheu, 35653, France. gael.le-trionnaire@inrae.fr.
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRInstitut de Recherche en Informatique et Systèmes Aléatoires · FRUniversité Paris Sciences et Lettres · FR

Funding

Agence Nationale de la Recherche ANR-09-GENM-017-001
6 · The paper itself

Abstract

backgroundTransitions from sexual to asexual reproduction are common in eukaryotes, but the underlying mechanisms remain poorly known. The pea aphid-Acyrthosiphon pisum-exhibits reproductive polymorphism, with cyclical parthenogenetic and obligate parthenogenetic lineages, offering an opportunity to decipher the genetic basis of sex loss. Previous work on this species identified a single 840 kb region controlling reproductive polymorphism and carrying 32 genes. With the aim of identifying the gene(s) responsible for sex loss and the resulting consequences on the genetic programs controlling sexual or asexual embryogenesis, we compared the transcriptomic response to photoperiod shortening-the main sex-inducing cue-of a sexual and an obligate asexual lineage of the pea aphid, focusing on heads (where the photoperiodic cue is detected) and embryos (the final target of the cue).

resultsOur analyses revealed that four genes (one expressed in the head, and three in the embryos) of the region responded differently to photoperiod in the two lineages. We also found that the downstream genetic programs expressed during embryonic development of a future sexual female encompass ∼1600 genes, among which miRNAs, piRNAs and histone modification pathways are overrepresented. These genes mainly co-localize in two genomic regions enriched in transposable elements (TEs).

conclusionsOur results suggest that the causal polymorphism(s) in the 840 kb region somehow impair downstream epigenetic and post-transcriptional regulations in obligate asexual lineages, thereby sustaining asexual reproduction.

Indexed as

AphidsAnimalsFemaleGene Expression ProfilingParthenogenesisPisum sativumReproduction, AsexualAsexualityCyclical and obligate parthenogenesisGene expressionInsectsReproductive polymorphism

Identifiers

PMID38383295
PMCPMC10882735
OpenAlexW4392014765

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.