Evidence map›Paper›PMID 38383231›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2024

Vitamin D status and variable responses to supplements depend in part on genetic factors in adults with cystic fibrosis.

Andrew T Braun, HuiChuan J Lai, Anita Laxova, Julie A Biller, Erin K Hubertz, Zijie Zhao, Qiongshi Lu, Sangita Murali, Donna M Brown, Elizabeth A Worthey and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Cystic fibrosis-related bone disease: an update on screening, diagnosis, and treatment.Therapeutic advances in endocrinology and metabolism · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andrew T BraunDepartment of Medicine, University of Wisconsin, Madison WI, USA. Electronic address: atbraun@medicine.wisc.edu.
HuiChuan J LaiDepartment of Pediatrics, University of Wisconsin, Madison WI, USA; Department of Nutritional Sciences, University of Wisconsin, Madison WI, USA.
Anita LaxovaDepartment of Pediatrics, University of Wisconsin, Madison WI, USA.
Julie A BillerDepartment of Medicine, Medical College of Wisconsin, Milwaukee WI, USA.
Erin K HubertzDepartment of Medicine, Medical College of Wisconsin, Milwaukee WI, USA.
Zijie ZhaoDepartment of Statistics, University of Wisconsin, Madison WI, USA; Department of Biostatistics & Medical Informatics, University of Wisconsin, Madison, WI, USA.
Qiongshi LuDepartment of Statistics, University of Wisconsin, Madison WI, USA; Department of Biostatistics & Medical Informatics, University of Wisconsin, Madison, WI, USA.
Sangita MuraliDepartment of Nutritional Sciences, University of Wisconsin, Madison WI, USA.
Donna M BrownDepartment of Genetics, Center for Computational Genomics and Data Science at the University of Alabama Birmingham, Marnix E. Heersink School of Medicine, Birmingham, AL, USA.
Elizabeth A WortheyDepartment of Genetics, Center for Computational Genomics and Data Science at the University of Alabama Birmingham, Marnix E. Heersink School of Medicine, Birmingham, AL, USA.
Philip M FarrellDepartment of Pediatrics, University of Wisconsin, Madison WI, USA.
University of Wisconsin–Madison · USMedical College of Wisconsin · USUniversity of Alabama at Birmingham · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
Early Childhood Diet, Growth, Gut Microbiome And Lung Health in Cystic FibrosisR01DK109692 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LAI, HUICHUAN J · 2016 to 2021
$3.8M
NIDDK NIH HHS P30 DK072482NIDDK NIH HHS R01 DK109692
6 · The paper itself

Abstract

Vitamin D sufficiency has been difficult to achieve consistently in patients with cystic fibrosis (CF), even with robust oral supplements. To assess vitamin D status and resistance to supplementation, we studied 80 adults using 25-hydroxyvitamin D (25OHD) determinations and whole genome sequencing to construct polygenic risk scores (PRS) that aggregate variants associated with vitamin D status. The results revealed that 30 % of patients were below the threshold of 30 ng/mL and thus should be regarded as insufficient despite normal vitamin E status, a reflection of adherence to fat soluble vitamin supplementation. The PRS values were significantly correlated with 25OHD concentrations, confirming our results in children with CF, and indicating that genetic factors play a role and have implications for therapy.

Indexed as

Cystic FibrosisDietary SupplementsVitamin DVitamin D DeficiencyAdultFemaleHumansMaleVitamins25-hydroxyvitamin DVitamin DVitamins25-hydroxyvitamin DCystic fibrosisPolygenic risk scoreSingle nucleotide polymorphismVitamin D supplementationWhole genome sequencing

Identifiers

PMID38383231
PMCPMC11624284
OpenAlexW4392005281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.