SynthesisJournal of neurology, neurosurgery, and psychiatry2024
Pain and functional neurological disorder: a systematic review and meta-analysis.
Synthesis in Journal of neurology, neurosurgery, and psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Prepulse inhibition of the blink reflex in functional neurological disorder and fibromyalgia.Brain : a journal of neurology · 2026Article
- Falls in Functional Neurological Disorder: Prevalence, Risk Factors and Clinical Implications.European journal of neurology · 2026Article
- Pain in Functional Motor Disorders: Clinical Correlates From the Italian Registry.European journal of neurology · 2026Article
- Pain-related disability in functional neurological disorder (FND): the role of pain intensity and psychological factors.Journal of neurology · 2026Article
- Exploring the Dynamic Relationship Between Migraine and Functional Neurological Disorders: A Narrative Review.Current pain and headache reports · 2026Review
- Who benefits from multidisciplinary care in functional somatic disorders? Identifying cost-effective patient selection through diagnostic classification groups.Israel journal of health policy research · 2026Article
- Characterisation of Chronic Pain Syndrome in Patients With Functional Neurological Disorder.European journal of pain (London, England) · 2026Article
- Exploring the autism and functional neurological disorder association: Considerations from biopsychosocial, neuropsychological and computational models.Autism : the international journal of research and practice · 2026Review
- Functional sensory symptoms and signs: a case-control study of 102 patients.Brain communications · 2026Article
- Cognitive rehabilitation for functional neurological disorder.CNS spectrums · 2025Review
- Functional cervical dystonia: diagnostic accuracy of distinct clinical features.Journal of neurology · 2025Article
- Adverse life events and psychosocial stressors in functional neurological disorder: a retrospective cohort and case-control study using a large international electronic health record database.EClinicalMedicine · 2025Article
- The Impact of Pregnancy on Functional Neurological Disorder (FND).European journal of neurology · 2025Article
- Platform Technology for Extended Reality Biofeedback Training Under Operant Conditioning for Functional Limb Weakness: Protocol for the Coproduction of an at-Home Solution (React2Home).JMIR research protocols · 2025Article
- Machine learning classification of functional neurological disorder using structural brain MRI features.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review.BMJ neurology open · 2025Article
- Delineating network integration and segregation in the pathophysiology of functional neurological disorder.Brain communications · 2025Article
- Migraine and functional neurological disorder (FND)-a review of comorbidity and potential overlap.Brain communications · 2025Review
- Positive signs from the history as an aid for early diagnosis in functional movement disorders: The prospective TASMAN study.European journal of neurology · 2025Article
- Functional neurological disorder, physical activity and exercise: What we know and what we can learn from comorbid disorders.Epilepsy & behavior reports · 2024Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional neurological disorder (FND) is characterised by neurological symptoms, such as seizures and abnormal movements. Despite its significance to patients, the clinical features of chronic pain in people with FND, and of FND in people with chronic pain, have not been comprehensively studied.
methodsWe systematically reviewed PubMed, Embase and PsycINFO for studies of chronic pain in adults with FND and FND in patients with chronic pain. We described the proportions of patients reporting pain, pain rating and timing, pain-related diagnoses and responsiveness to treatment. We performed random effects meta-analyses of the proportions of patients with FND who reported pain or were diagnosed with pain-related disorders.
resultsSeven hundred and fifteen articles were screened and 64 were included in the analysis. Eight case-control studies of 3476 patients described pain symptoms in a higher proportion of patients with FND than controls with other neurological disorders. A random effects model of 30 cohorts found that an estimated 55% (95% CI 46% to 64%) of 4272 patients with FND reported pain. Random effects models estimated diagnoses of complex regional pain syndrome in 22% (95% CI 6% to 39%) of patients, irritable bowel syndrome in 16% (95% CI 9% to 24%) and fibromyalgia in 10% (95% CI 8% to 13%). Five studies of FND diagnoses among 361 patients with chronic pain were identified. Most interventions for FND did not ameliorate pain, even when other symptoms improved.
conclusionsPain symptoms and pain-related diagnoses are common in FND. Classification systems and treatments should routinely consider pain as a comorbidity in patients with FND.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.